HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bajc, M. Articles by Jonson, B. Search for Related Content PubMed PubMed Citation Articles by Bajc, M. Articles by Jonson, B.

Lung Ventilation/Perfusion SPECT in the Artificially Embolized Pig

¹ Department of Clinical Physiology, Lund University Hospital, Lund, Sweden
² Department of Anesthesiology, Lund University Hospital, Lund, Sweden
³ Department of Radiation Physics, Lund University Hospital, Lund, Sweden

Planar lung scintigraphy is a standard method used for the diagnosis of lung embolism, but it is hampered by the high incidence of nondiagnostic tests. Ventilation/perfusion SPECT may possibly improve this situation. The objective of this study was to compare planar lung scintigraphy with ventilation/perfusion SPECT using pigs with artificially engendered lung emboli labeled with ²⁰¹Tl. Methods: Sixteen anesthetized pigs were each injected with zero to 4 latex emboli. Cylindric emboli were used in the first 7 pigs and flat 3-tailed emboli were used in the remaining 9 pigs. The pigs spontaneously inhaled 30 MBq ^99mTc-diethylenetriaminepentaacetic acid aerosol for ventilation scintigraphy. Planar scintigraphy and SPECT were performed using a double-head gamma camera in ^99mTc and ²⁰¹Tl windows. Immediately thereafter, 100 MBq ^99mTc-labeled macroaggregated albumin were injected intravenously followed by SPECT and, finally, planar scintigraphy. The ventilation background was subtracted from the perfusion tomograms for calculation of a normalized ventilation/perfusion (V/P) quotient image set. Results: The cylindric emboli caused artifacts in the ventilation images; therefore, these were excluded from the final analysis. However, for the planar perfusion images of these pigs, sensitivity and specificity were 71% and 91%, respectively, whereas SPECT yielded 100% for both. For the 3-tailed emboli and ventilation/perfusion images, the sensitivity and specificity were 64% and 79%, respectively, for the planar modality, whereas SPECT yielded values of 91% and 87%, respectively. Conclusion: V/P SPECT may improve the diagnostic power of lung scintigraphy.

Key Words: lungs • SPECT • embolism • ventilation • perfusion • pig

This article has been cited by other articles:

				H. Gutte, J. Mortensen, C. V. Jensen, C. B. Johnbeck, P. von der Recke, C. L. Petersen, J. Kjaergaard, U. S. Kristoffersen, and A. Kjaer Detection of Pulmonary Embolism with Combined Ventilation-Perfusion SPECT and Low-Dose CT: Head-to-Head Comparison with Multidetector CT Angiography J. Nucl. Med., December 1, 2009; 50(12): 1987 - 1992. [Abstract] [Full Text] [PDF]

				J. Burrill, Z. Dabbagh, F. Gollub, and M. Hamady Multidetector computed tomographic angiography of the cardiovascular system Postgrad. Med. J., November 1, 2007; 83(985): 698 - 704. [Abstract] [Full Text] [PDF]

				B. Harris, D. Bailey, S. Miles, E. Bailey, K. Rogers, P. Roach, P. Thomas, M. Hensley, and G. G. King Objective Analysis of Tomographic Ventilation-Perfusion Scintigraphy in Pulmonary Embolism Am. J. Respir. Crit. Care Med., June 1, 2007; 175(11): 1173 - 1180. [Abstract] [Full Text] [PDF]

				P. Reinartz, H.-J. Kaiser, J. E. Wildberger, C. Gordji, B. Nowak, and U. Buell SPECT Imaging in the Diagnosis of Pulmonary Embolism: Automated Detection of Match and Mismatch Defects by Means of Image-Processing Techniques J. Nucl. Med., June 1, 2006; 47(6): 968 - 973. [Abstract] [Full Text] [PDF]

				S. Patel and E. A. Kazerooni Reply Am. J. Roentgenol., April 1, 2006; 186(4): 1200 - 1201. [Full Text] [PDF]

				P. Reinartz, J. E. Wildberger, W. Schaefer, B. Nowak, A. H. Mahnken, and U. Buell Tomographic Imaging in the Diagnosis of Pulmonary Embolism: A Comparison Between V/Q Lung Scintigraphy in SPECT Technique and Multislice Spiral CT J. Nucl. Med., September 1, 2004; 45(9): 1501 - 1508. [Abstract] [Full Text] [PDF]

				P. Reinartz, B. Nowak, C. Weiss, U. Buell, E. Coche, V. Roelants, A. Keyeux, F. Verschuren, and F. Zech Acute Pulmonary Embolism: Thin-Collimation Spiral CT versus Planar Ventilation-Perfusion Scintigraphy * Dr Coche and colleagues respond: Radiology, August 1, 2004; 232(2): 621 - 622. [Full Text] [PDF]

				U. J. Schoepf, S. Z. Goldhaber, and P. Costello Spiral Computed Tomography for Acute Pulmonary Embolism Circulation, May 11, 2004; 109(18): 2160 - 2167. [Abstract] [Full Text] [PDF]

				A. Perrier Labeling the Thrombus: The Future of Nuclear Medicine for Venous Thromboembolism? Am. J. Respir. Crit. Care Med., May 1, 2004; 169(9): 977 - 978. [Full Text] [PDF]

				U. J. Schoepf and P. Costello CT Angiography for Diagnosis of Pulmonary Embolism: State of the Art Radiology, February 1, 2004; 230(2): 329 - 337. [Abstract] [Full Text] [PDF]

				M. A. Meignan Lung Ventilation/Perfusion SPECT: The Right Technique for Hard Times J. Nucl. Med., May 1, 2002; 43(5): 648 - 651. [Full Text] [PDF]