HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Madar, I. Articles by Izbicki, G. Search for Related Content PubMed PubMed Citation Articles by Madar, I. Articles by Izbicki, G.

Preferential Accumulation of ³H-Tetraphenylphosphonium in Non–Small Cell Lung Carcinoma in Mice: Comparison with ^99mTc-MIBI

¹ Department of Medical Biophysics and Nuclear Medicine, Hadassah University Medical Center, Jerusalem, Israel
² Department of Immunology, Hadassah University Medical Center, Jerusalem, Israel
³ Department of Pulmonary Research, Hadassah University Medical Center, Jerusalem, Israel

We have previously shown enhanced accumulation of the delocalized lipophilic cation ¹¹C-triphenylmethylphosphonium in canine brain glioma, suggesting its potential use for tumor staging in humans using PET. Here, we extend our studies of phosphonium cations to nonbrain tumors and characterize the biodistribution and tumor specificity of ³H-tetraphenylphosphonium (³H-TPP) in non–small cell lung carcinoma in mice. Methods: ³H-TPP accumulation in isolated malignant lung nodules of the Lewis lung carcinoma (LLC) cell line, in LLC-bearing lung, and in control lung was measured at various intervals after inoculation. Tumor uptake and biodistribution of ³H-TPP were compared with those of ^99mTc-methoxyisobutylisonitrile (MIBI). Results: ³H-TPP accumulation in LLC nodules at 14 d was significantly greater than that in controls, peaked at 21 d, and declined to lower values at 28 d after injection. At 21 d after injection, ³H-TPP uptake in LLC nodules was greater than that in control lung tissue and in LLC-bearing lung tissue—by 549% and 230%, respectively—whereas ^99mTc-MIBI nodule uptake was greater by 90% and 30%, respectively. Conclusion: The high tumor accumulation and sensitivity to the phase of tumor development suggest the potential use of radiolabeled phosphonium analogs for in vivo tumor staging and as a tool for investigating tumor evolution.

Key Words: tetraphenylphosphonium • non–small cell lung carcinoma • mouse model

This article has been cited by other articles:

				Z. Cheng, R. C. Winant, and S. S. Gambhir A New Strategy to Screen Molecular Imaging Probe Uptake in Cell Culture Without Radiolabeling Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry J. Nucl. Med., May 1, 2005; 46(5): 878 - 886. [Abstract] [Full Text] [PDF]

				J. R. Ballinger and S. S. Gambhir Re: Tetraphenylphosphonium as a Novel Molecular Probe for Imaging Tumors J. Nucl. Med., December 1, 2004; 45(12): 2126 - 2126. [Full Text] [PDF]

				J.-J. Min, S. Biswal, C. Deroose, and S. S. Gambhir Tetraphenylphosphonium as a Novel Molecular Probe for Imaging Tumors J. Nucl. Med., April 1, 2004; 45(4): 636 - 643. [Abstract] [Full Text] [PDF]