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Biodistribution of ^99mTc-O₄Na Changes in Adult Rats Whose Mothers Were Malnourished During Lactation

¹ Departamento de Nutrição Aplicada, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil
² Departamento de Anatomia, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil
³ Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil
⁴ Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil

^99mTc-O₄Na biodistribution changes in malnourished adults rats. We evaluated this biodistribution in rats whose mothers were malnourished during lactation. Methods: On the first day of lactation the mothers were separated into 3 groups: control (C) group, protein-restricted (PR) group, and energy-restricted (ER) group. After weaning all pups received a control diet until 60 d, when they were injected with ^99mTc-O₄Na and killed after 30 min. We evaluated the absolute percentage injected dose (%ID) and the %ID per gram (%ID/g) in thyroid, stomach, heart, bone, kidney, lung, liver, brain, and testes. Results: In the PR group, the %ID and %ID/g were significantly higher in the stomach and lower in the thyroid than in the C group. In the ER pups, the %ID and %ID/g were higher in the liver, stomach, and testes than in the C group. Conclusion: The mother’s nutritional status during lactation affects the biodistribution of ^99mTc-O₄Na in the offspring, and this condition must be considered when nuclear medicine examinations are indicated.

Key Words: protein restriction • energy restriction • lactation • ^99mTc-O₄Na