HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sciuto, R. Articles by Maini, C. L. Search for Related Content PubMed PubMed Citation Articles by Sciuto, R. Articles by Maini, C. L.

Effects of Low-Dose Cisplatin on ⁸⁹Sr Therapy for Painful Bone Metastases from Prostate Cancer: A Randomized Clinical Trial

Nuclear Medicine Department, Regina Elena Cancer Institute, Rome, Italy

This study evaluated the effects of low-dose cisplatin plus ⁸⁹Sr versus ⁸⁹Sr alone in the treatment of painful bone metastases from prostate cancer, addressing both pain palliation and cytostatic effects. Methods: Seventy patients with metastatic hormone-refractory prostate cancer were randomized into 2 groups: One group (arm A) received 148 MBq ⁸⁹Sr plus 50 mg/m² cisplatin, and the other group (arm B) received 148 MBq ⁸⁹Sr plus placebo. After treatment, the patients were followed up until death to evaluate the outcome variables: grade and duration of pain palliation, onset of new painful sites, changes in bone disease, global survival, serum prostate-specific antigen and alkaline phosphatase changes, and hematologic toxicity. Results: Overall pain relief occurred in 91% of patients in arm A and 63% of patients in arm B (P < 0.01), with a median duration of 120 d in arm A and 60 d in arm B (P = 0.002). New painful sites on previously asymptomatic bone metastases appeared in 14% of patients in arm A and in 30% of patients in arm B (P = 0.18). The median survival without new painful sites was 4 mo in arm A and 2 mo in arm B (P = 0.04). Bone disease progression was observed in 27% of patients in arm A and in 64% of patients in arm B (P = 0.01). Median global survival after therapy was 9 mo in arm A and 6 mo in arm B (P = 0.30). Transient and moderate hematologic toxicity, as determined by World Health Organization criteria, was apparent in both arms without significant differences. Conclusion: The addition of a low dose of cisplatin enhances the effect of a standard dose of ⁸⁹Sr without significant side effects, producing a significant improvement in pain palliation and a cytostatic effect on bone disease.

Key Words: strontium • cisplatin • pain palliation • prostate cancer

This article has been cited by other articles:

				K. Fizazi, P. Beuzeboc, J. Lumbroso, V. Haddad, C. Massard, M. Gross-Goupil, M. Di Palma, B. Escudier, C. Theodore, Y. Loriot, et al. Phase II Trial of Consolidation Docetaxel and Samarium-153 in Patients With Bone Metastases From Castration-Resistant Prostate Cancer J. Clin. Oncol., May 20, 2009; 27(15): 2429 - 2435. [Abstract] [Full Text] [PDF]

				O. S. Bruland, S. Nilsson, D. R. Fisher, and R. H. Larsen High-Linear Energy Transfer Irradiation Targeted to Skeletal Metastases by the {alpha}-Emitter 223Ra: Adjuvant or Alternative to Conventional Modalities? Clin. Cancer Res., October 15, 2006; 12(20): 6250s - 6257s. [Abstract] [Full Text] [PDF]

				S.-M. Tu, J. Kim, L. C. Pagliaro, F. Vakar-Lopez, F. C. Wong, S. Wen, R. General, D. A. Podoloff, S.-H. Lin, and C. J. Logothetis Therapy Tolerance in Selected Patients With Androgen-Independent Prostate Cancer Following Strontium-89 Combined With Chemotherapy J. Clin. Oncol., November 1, 2005; 23(31): 7904 - 7910. [Abstract] [Full Text] [PDF]

				K. Liepe, R. Runge, and J. Kotzerke Systemic radionuclide therapy in pain palliation American Journal of Hospice and Palliative Medicine, November 1, 2005; 22(6): 457 - 464. [Abstract] [PDF]

				H. Schoder, A. Noy, M. Gonen, L. Weng, D. Green, Y. E. Erdi, S. M. Larson, and H. W.D. Yeung Intensity of 18Fluorodeoxyglucose Uptake in Positron Emission Tomography Distinguishes Between Indolent and Aggressive Non-Hodgkin's Lymphoma J. Clin. Oncol., July 20, 2005; 23(21): 4643 - 4651. [Abstract] [Full Text] [PDF]

				S. Nilsson, R. H. Larsen, S. D. Fossa, L. Balteskard, K. W. Borch, J.-E. Westlin, G. Salberg, and O. S. Bruland First Clinical Experience with {alpha}-Emitting Radium-223 in the Treatment of Skeletal Metastases Clin. Cancer Res., June 15, 2005; 11(12): 4451 - 4459. [Abstract] [Full Text] [PDF]

				V. J. Lewington Bone-Seeking Radionuclides For Therapy J. Nucl. Med., January 1, 2005; 46(1_suppl): 38S - 47S. [Abstract] [Full Text] [PDF]

				H. Palmedo, A. Manka-Waluch, P. Albers, I. G.H. Schmidt-Wolf, M. Reinhardt, S. Ezziddin, A. Joe, R. Roedel, R. Fimmers, F.F. Knapp Jr, et al. Repeated Bone-Targeted Therapy for Hormone-Refractory Prostate Carcinoma: Randomized Phase II Trial With the New, High-Energy Radiopharmaceutical Rhenium-188 Hydroxyethylidenediphosphonate J. Clin. Oncol., August 1, 2003; 21(15): 2869 - 2875. [Abstract] [Full Text] [PDF]

				A. J.B. McEwan Radioisotope Therapy and Clinical Trial Design: The Need for Consensus and Innovation J. Nucl. Med., January 1, 2002; 43(1): 87 - 88. [Full Text] [PDF]