HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schöder, H. Articles by Czernin, J. Search for Related Content PubMed PubMed Citation Articles by Schöder, H. Articles by Czernin, J.

Effect of Whole-Body ¹⁸F-FDG PET Imaging on Clinical Staging and Management of Patients with Malignant Lymphoma

Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic/Nuclear Medicine, University of California, Los Angeles, School of Medicine, Los Angeles; and Northern California PET Imaging Center, Sacramento, California

Correct staging is important in selecting the appropriate treatment for lymphoma patients. PET imaging with ¹⁸F-FDG is useful for staging of lymphoma as well as for monitoring of therapy. However, to our knowledge, the clinical impact of PET on staging and management of lymphoma patients has not been reported. Methods: Standardized questionnaires were mailed to referring physicians asking them whether and how the results of PET imaging had influenced clinical staging and management of the disease in their patients. Management changes, when present, were classified as intermodality (e.g., medical to surgical, surgical to radiation, medical to no treatment) or intramodality (e.g., altered medical, surgical, or radiotherapy approach). Results: The referring physicians returned 52 of 108 questionnaires (48.1%). Physicians indicated that PET led to a change in the clinical stage in 44% of patients: 21% were upstaged and 23% were downstaged. Findings of the PET examination resulted in intermodality changes in management in 42% of patients, in intramodality changes in 10%, and in a combination of the management changes in 10%. Other, not further specified, treatment changes were reported in 6% of patients. PET did not result in any management changes in only 32% of patients. Conclusion: This survey-based study of referring physicians indicates that FDG PET has a major impact on the management of lymphoma patients, contributing to changes in clinical stage in 44% and changes in treatment in >60% of cases.

Key Words: lymphoma • ¹⁸F-FDG • PET • patient management

This article has been cited by other articles:

				B. E. Hillner, D. Liu, R. E. Coleman, A. F. Shields, I. F. Gareen, L. Hanna, S. H. Stine, and B. A. Siegel The National Oncologic PET Registry (NOPR): Design and Analysis Plan J. Nucl. Med., November 1, 2007; 48(11): 1901 - 1908. [Abstract] [Full Text] [PDF]

				M. J. Lindsay, B. A. Siegel, S. R. Tunis, B. E. Hillner, A. F. Shields, B. P. Carey, and R. E. Coleman The National Oncologic PET Registry: Expanded Medicare Coverage for PET Under Coverage with Evidence Development Am. J. Roentgenol., April 1, 2007; 188(4): 1109 - 1113. [Abstract] [Full Text] [PDF]

				M. Hadithi, M. Mallant, J. Oudejans, J.-H. T.M. van Waesberghe, C. J. Mulder, and E. F.I. Comans 18F-FDG PET Versus CT for the Detection of Enteropathy-Associated T-Cell Lymphoma in Refractory Celiac Disease J. Nucl. Med., October 1, 2006; 47(10): 1622 - 1627. [Abstract] [Full Text] [PDF]

				Y. S. Jhanwar and D. J. Straus The Role of PET in Lymphoma J. Nucl. Med., August 1, 2006; 47(8): 1326 - 1334. [Abstract] [Full Text] [PDF]

				E. Y. Tsai, A. Taur, L. Espinosa, A. Quon, D. Johnson, S. Dick, S. Chow, R. Advani, R. Warnke, S. Kohler, et al. Staging accuracy in mycosis fungoides and sezary syndrome using integrated positron emission tomography and computed tomography. Arch Dermatol, May 1, 2006; 142(5): 577 - 584. [Abstract] [Full Text] [PDF]

				H. Schoder, A. Noy, M. Gonen, L. Weng, D. Green, Y. E. Erdi, S. M. Larson, and H. W.D. Yeung Intensity of 18Fluorodeoxyglucose Uptake in Positron Emission Tomography Distinguishes Between Indolent and Aggressive Non-Hodgkin's Lymphoma J. Clin. Oncol., July 20, 2005; 23(21): 4643 - 4651. [Abstract] [Full Text] [PDF]

				B. E. Hillner, R. Tunuguntla, and M. Fratkin Clinical Decisions Associated With Positron Emission Tomography in a Prospective Cohort of Patients With Suspected or Known Cancer at One United States Center J. Clin. Oncol., October 15, 2004; 22(20): 4147 - 4156. [Abstract] [Full Text] [PDF]

				J. E. Thompson and C. B. Thompson Putting the Rap on Akt J. Clin. Oncol., October 15, 2004; 22(20): 4217 - 4226. [Abstract] [Full Text] [PDF]

				W. B. Eubank, D. Mankoff, M. Bhattacharya, J. Gralow, H. Linden, G. Ellis, S. Lindsley, M. Austin-Seymour, and R. Livingston Impact of FDG PET on Defining the Extent of Disease and on the Treatment of Patients with Recurrent or Metastatic Breast Cancer Am. J. Roentgenol., August 1, 2004; 183(2): 479 - 486. [Abstract] [Full Text] [PDF]

				H. Agress Jr and B. Z. Cooper Detection of Clinically Unexpected Malignant and Premalignant Tumors with Whole-Body FDG PET: Histopathologic Comparison Radiology, February 1, 2004; 230(2): 417 - 422. [Abstract] [Full Text] [PDF]

				M Hoffmann, H Vogelsang, K Kletter, G Zettinig, A Chott, and M Raderer 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) for assessment of enteropathy-type T cell lymphoma Gut, March 1, 2003; 52(3): 347 - 351. [Abstract] [Full Text] [PDF]

				M. A. Seltzer, C. S. Yap, D. H. Silverman, J. Meta, C. Schiepers, M. E. Phelps, S. S. Gambhir, J. Rao, P. E. Valk, and J. Czernin The Impact of PET on the Management of Lung Cancer: The Referring Physician's Perspective J. Nucl. Med., June 1, 2002; 43(6): 752 - 756. [Abstract] [Full Text] [PDF]