HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ahn, J. Y. Articles by Lee, M. C. Search for Related Content PubMed PubMed Citation Articles by Ahn, J. Y. Articles by Lee, M. C.

Quantification of Regional Myocardial Blood Flow Using Dynamic H₂¹⁵O PET and Factor Analysis

Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul; Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul; and Department of Physics, Ewha Womans University, Seoul, Korea

Because the use of factor analysis has been proposed for extracting pure physiologic temporal or spatial information from dynamic nuclear medicine images, factor analysis should be capable of robustly estimating regional myocardial blood flow (rMBF) using H₂¹⁵O PET without additional C¹⁵O PET, which is a cumbersome procedure for patients. Therefore, we measured rMBF using time–activity curves (TACs) obtained from factor analysis of dynamic myocardial H₂¹⁵O PET images without the aid of C¹⁵O PET. Methods: H₂¹⁵O PET of six healthy dogs at rest and during stress was performed simultaneously with microsphere studies using ⁸⁵Sr, ⁴⁶Sc, and ¹¹³Sn. We performed factor analysis in two steps after reorienting and masking the images to include only the cardiac region. The first step discriminated each factor in the spatial distribution and acquired the input functions, and the second step extracted regional-tissue TACs. Image-derived input functions obtained by factor analysis were compared with those obtained by the sampling method. rMBF calculated using a compartmental model with tissue TACs from the second step of the factor analysis was compared with rMBF measured by microsphere studies. Results: Factor analysis was successful for all the dynamic H₂¹⁵O PET images. The input functions obtained by factor analysis were nearly equal to those obtained by arterial blood sampling, except for the expected delay. The correlation between rMBF obtained by factor analysis and rMBF obtained by microsphere studies was good (r = 0.95). The correlation between rMBF obtained by the region-of-interest method and rMBF obtained by microsphere studies was also good (r = 0.93). Conclusion: rMBF can be measured robustly by factor analysis using dynamic myocardial H₂¹⁵O PET images without additional C¹⁵O blood-pool PET.

Key Words: H₂¹⁵O PET • factor analysis • regional myocardial blood flow

This article has been cited by other articles:

				J. S. Lee, D. S. Lee, J. Y. Ahn, J. S. Yeo, G. J. Cheon, S.-K. Kim, K. S. Park, J.-K. Chung, and M. C. Lee Generation of Parametric Image of Regional Myocardial Blood Flow Using H215O Dynamic PET and a Linear Least-Squares Method J. Nucl. Med., October 1, 2005; 46(10): 1687 - 1695. [Abstract] [Full Text] [PDF]

				P. A. Kaufmann and P. G. Camici Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications J. Nucl. Med., January 1, 2005; 46(1): 75 - 88. [Full Text] [PDF]

				C. Katoh, K. Morita, T. Shiga, N. Kubo, K. Nakada, and N. Tamaki Improvement of Algorithm for Quantification of Regional Myocardial Blood Flow Using 15O-Water with PET J. Nucl. Med., November 1, 2004; 45(11): 1908 - 1916. [Abstract] [Full Text] [PDF]

				A. N. Mazzadi, M. F. Janier, B. Brossier, X. Andre-Fouet, D. Revel, and P. Croisille Tagged MRI and PET in severe CAD: discrepancy between preoperative inotropic reserve and intramyocardial functional outcome after revascularization Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2226 - H2233. [Abstract] [Full Text] [PDF]

				A. N. Mazzadi, M. F. Janier, B. Brossier, X. Andre-Fouet, E. McFadden, D. Revel, and P. Croisille Dobutamine-tagged MRI for inotropic reserve assessment in severe CAD: relationship with PET findings Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1946 - H1953. [Abstract] [Full Text] [PDF]

				P. Koepfli, T. F. Hany, C. A. Wyss, M. Namdar, C. Burger, A. V. Konstantinidis, T. Berthold, G. K. von Schulthess, and P. A. Kaufmann CT Attenuation Correction for Myocardial Perfusion Quantification Using a PET/CT Hybrid Scanner J. Nucl. Med., April 1, 2004; 45(4): 537 - 542. [Abstract] [Full Text] [PDF]

				A. N. Mazzadi, X. Andre-Fouet, J. Duisit, V. Gebuhrer, N. Costes, P. Chevalier, C. Rodriguez, J.-J. Schott, H. Le Marec, P. Guicheney, et al. Cardiac retention of [11C]HED in genotyped long QT patients: a potential amplifier role for severity of the disease Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1286 - H1293. [Abstract] [Full Text] [PDF]

				C. A. Wyss, P. Koepfli, K. Mikolajczyk, C. Burger, G. K. von Schulthess, and P. A. Kaufmann Bicycle Exercise Stress in PET for Assessment of Coronary Flow Reserve: Repeatability and Comparison with Adenosine Stress J. Nucl. Med., February 1, 2003; 44(2): 146 - 154. [Abstract] [Full Text] [PDF]