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Journal of Nuclear Medicine Vol. 42 No. 5 733-737
© 2001 by Society of Nuclear Medicine

CLINICAL INVESTIGATIONS

Receptor Measurements via Tc-GSA Kinetic Modeling Are Proportional to Functional Hepatocellular Mass

Kenji Miki, Keiichi Kubota, Yusuke Inoue, David R. Vera and Masatoshi Makuuchi

Departments of Hepato-Biliary-Pancreatic Surgery and Radiology, Faculty of Medicine, University of Tokyo, Tokyo, Japan; and Department of Radiology, University of California, San Diego, La Jolla, California

Kinetic modeling of 99mTc-diethylenetriaminepentaacetic acid galactosyl human serum albumin (Tc-GSA) measures the total amount of asialoglycoprotein receptor within a subject’s liver. This study tested the hypothesis that the amount of asialoglycoprotein receptor measured by Tc-GSA modeling provides a valid index of functional liver mass. Methods: Twenty-two patients with cirrhosis, 18 patients with chronic hepatitis, and 9 patients with normal liver parenchyma were studied with Tc-GSA using a 30-min dynamic imaging protocol. The total amount of hepatic receptor was measured by kinetic modeling of the Tc-GSA time–activity data. The total number of viable hepatocytes was calculated using standard morphometric measurements of liver biopsy samples and liver volume measurements through CT. Results: The total receptor amount strongly correlated with the total hepatocyte number (r = 0.803; P < 0.0001). Conclusion: Tc-GSA measurement of the total receptor amount is proportional to the number of viable hepatocytes and therefore provides a valid assessment of functional liver mass.

Key Words: 99mTc-diethylenetriaminepentaacetic acid galactosyl human serum albumin • asialoglycoprotein receptor • functional liver mass • kinetic modeling






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Copyright © 2001 by the Society of Nuclear Medicine.