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Journal of Nuclear Medicine Vol. 42 No. 4 575-578
© 2001 by Society of Nuclear Medicine

CLINICAL INVESTIGATIONS

Use of 201Tl SPECT for Evaluation of Biologic Behavior in Pituitary Adenomas

Takahiro Nakano, Kenichiroh Asano, Masahiko Tanaka, Toshio Takahashi, Hiroyuki Miura and Shigeharu Suzuki

Departments of Neurosurgery and Radiology, Hirosaki University School of Medicine, Hirosaki, Japan

Although pituitary adenomas are regarded as benign tumors, some of them behave aggressively with malignant behavior of invasion and metastasis. Prediction of such biologic behavior in a tumor is important for therapeutic planning. The purpose of this study was to assess the usefulness of 201Tl chloride SPECT (201Tl SPECT) for evaluation of biologic behavior in pituitary adenomas. Methods: 201Tl SPECT was performed on 22 patients with pituitary adenomas. 201Tl uptake indices were calculated, and the results were compared between invasive pituitary adenomas and noninvasive pituitary adenomas. Correlation of the 201Tl uptake index and the MIB1 monoclonal antibody labeling index (MIB1 labeling index) of the tumors was also estimated. Results: In comparison with noninvasive pituitary adenomas, invasive pituitary adenomas exhibited significantly higher 201Tl uptake indices on both the early and the delayed images (P = 0.0010 and 0.0019, respectively). A significant correlation was found between the 201Tl uptake index on the delayed image and the MIB1 labeling index (P = 0.0107). Conclusion: 201Tl SPECT can be useful for detecting biologic aggressiveness in pituitary adenomas.

Key Words: pituitary adenoma • 201Tl SPECT • invasion • MIB1 monoclonal antibody






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Copyright © 2001 by the Society of Nuclear Medicine.