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Iodine-Labeled Tamoxifen Uptake in Primary Human Breast Carcinoma

Divisions of Nuclear Medicine, Medical Oncology, and Oncological Gynaecology and Department of Anatomopathology, Ghent University Hospital, Ghent; and Department of Radiopharmacy, Ghent University, Ghent, Belgium

Assessing tumor uptake and retention of ¹²³I-labeled tamoxifen (TX) could increase our understanding of TX’s action and the mechanisms involved in resistance to the drug. Methods: Nine untreated primary breast carcinoma patients underwent whole-body planar and tomographic (SPECT) imaging 30 min and 4–5 h after injection of 185 MBq ¹²³I-TX. Tumor-to-normal tissue uptake ratios (T/N) derived from SPECT images were related to estrogen receptor (ER) and progesteron receptor (PR) status. Results: In 4 of 9 patients, all of whom were ER+/PR+, ¹²³I-TX tumor uptake was clearly depicted. In 2 of them, involved axillary lymph nodes were also visualized. T/N consistently increased over time. All ER+/PR- and ER-/PR- tumors as well as 2 ER+/PR+ tumors were ¹²³I-TX-. Conclusion: These preliminary findings suggest that ¹²³I-TX is preferentially taken up in -ER+/PR+ breast tumors known to be more likely to respond to endocrine treatment.

Key Words: iodine-labeled tamoxifen • breast carcinoma

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