HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ollier, M. Articles by Madelmont, J.-C. Search for Related Content PubMed PubMed Citation Articles by Ollier, M. Articles by Madelmont, J.-C.

Joint Scintigraphy in Rabbits with ^99mTc-N-[3-(triethylammonio)propyl]-15ane-N5, a New Radiodiagnostic Agent for Articular Cartilage Imaging

Institut National de la Santé et de la Recherche Médicale, Clermont-Ferrand; Centre Jean Perrin, Clermont-Ferrand; and Université d^'Auvergne, Clermont-Ferrand, France

The aim of this study was to investigate joint scintigraphy in rabbits with ^99mTc-N-[3-(triethylammonio)propyl]-15ane-N5 (NTP 15-5), a new radiopharmaceutical that specifically localizes in cartilaginous tissues. Methods: Scans obtained after intravenous injection of the ^99mTc-labeled compound in normal and arthropathy-induced rabbits were compared with those of the bone-imaging agent ^99mTc–methylene diphosphonate (^99mTc–MDP). Results: The radioactive uptake of ^99mTc–NTP 15-5 was detected in cartilaginous tissues 5 min after injection and was stable for 2 h. The uptake intensity was related to age and joint disease severity, and cartilage alterations not revealed by radiography induced a significant decrease of radiotracer uptake. On the other hand, imaging performed with ^99mTc–MDP did not reveal the early changes in arthrosis but was more specific for bone remodeling in advanced stages of diseases or in inflammatory processes. Conclusion: Our results indicate that ^99mTc–NTP 15-5 could be a good tracer for human arthrosic and arthritic cartilage detection, especially for the early diagnosis of joint diseases.

Key Words: joint scintigraphy • cartilage imaging • polyazamacrocycles • quaternary ammonium

This article has been cited by other articles:

				L. Sarda-Mantel and D. Le Guludec Molecular Imaging of Cartilage J. Nucl. Med., September 1, 2009; 50(9): 1391 - 1393. [Full Text] [PDF]

				E. Miot-Noirault, F. Gouin, A. Vidal, M. Rapp, J. Maublant, S. Askienazy, J.-M. Chezal, D. Heymann, F. Redini, and N. Moins First Preclinical Imaging of Primary Cartilage Neoplasm and Its Local Recurrence Using 99mTc-NTP 15-5 Radiotracer J. Nucl. Med., September 1, 2009; 50(9): 1541 - 1547. [Abstract] [Full Text] [PDF]