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Image Fusion Using an Integrated, Dual-Head Coincidence Camera with X-Ray Tube-Based Attenuation Maps

Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee

Correspondence: For correspondence or reprints contact: James A. Patton, PhD, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 21st Ave. S. and Garland, Nashville, TN 37232-2675.

ABSTRACT

The purpose of this study was to characterize a dual-head gamma camera capable of FDG imaging using coincidence detection and equipped with an integrated x-ray transmission system for attenuation correction, anatomic mapping, and image fusion. Methods: Radiation dose (425 mrads skin dose) and tissue contrast (0.7% deviation from expected values) were assessed for the x-ray system. Registration of transmission and emission scans was validated using a hot sphere phantom and was verified in selected patient studies. Results: Fusion of anatomic maps and FDG images allowed precise anatomic localization of lesions identified using dual-head coincidence imaging. Conclusion: The combined approach of x-ray attenuation, anatomic mapping, and image fusion with scintigraphic studies provides a new diagnostic tool for nuclear medicine and fertile ground for future research.

Key Words: x-ray attenuation • coincidence imaging • image fusion