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Scintimammography with 11ß-Methoxy-(17,20Z)-[¹²³I]Iodovinylestradiol: A Complementary Role to ^99mTc-Methoxyisobutyl Isonitrile in the Characterization of Breast Tumors

Department of Nuclear Medicine and Radiobiology and Department of Surgery, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Québec, Canada

Correspondence: For correspondence or reprints contact: Johan E. van Lier, PhD, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine, University de Sherbrooke, 3001,12th Ave. N., Sherbrooke, Quebec, Canada J1H 5N4.

ABSTRACT

The aim of this study was to investigate a possible relationship between ^99mTc-methoxyisobutyl isonitrile (MIBI) uptake and the estrogen receptor (ER) status of breast tumors as determined by 11ß-methoxy-(17,20Z)-[¹²³I]iodovinylestradiol (MIVE) scintimammography. Methods: Thirteen patients referred for MIVE scintimammography after abnormal mammography or finding of a suspect mass on physical examination were injected intravenously with MIVE. Planar images of the breasts and axillary region were taken with both radiopharmaceuticals and compared with pathologic examination of the tumor tissue and in vitro ER quantification. Results: The presence of cancerous tissue, as indicated by MIBI uptake, is a prerequisite for the accumulation of MIVE by the breast tumors. There was no statistically significant correlation between the MIBI and MIVE tumor uptake ratios. However, the latter correlate well with the presence of ER, as determined by an in vitro assay. Conclusion: MIVE scans add unique information concerning the tumor ER status in breast cancer patients, which could contribute to a better characterization of the tumor and aid in the selection of the most appropriate treatment protocol.

Key Words: estrogen receptors • iodovinylestradiol • MIVE • ¹²³I • breast cancer • MIBI

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				J R Buscombe Scintimammography Imaging, September 1, 2001; 13(3): 164 - 170. [Abstract] [Full Text] [PDF]