HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vallejo, E. Articles by Sinusas, A. J. Search for Related Content PubMed PubMed Citation Articles by Vallejo, E. Articles by Sinusas, A. J.

Reproducibility and Accuracy of Gated SPECT for Determination of Left Ventricular Volumes and Ejection Fraction: Experimental Validation Using MRI

Experimental Nuclear Cardiology Laboratory, Division of Cardiovascular Medicine, Department of Internal Medicine
Department of Diagnostic Radiology
Department of Surgery, School of Medicine, Yale University, New Haven, Connecticut

Correspondence: For correspondence or reprints contact: Albert J. Sinusas, MD, Department of Nuclear Cardiology, Yale University School of Medicine, 333 Cedar St., P.O. Box 208042, New Haven, CT 06520-8042.

ABSTRACT

Quantitative gated SPECT (QGS) has been used for computation of left ventricular volumes and ejection fraction. This study evaluated, first, the effect of injected dose, time of imaging, and background activity on the reproducibility of QGS and, second, the accuracy of QGS, compared with cine MRI, for determining left ventricular volumes and ejection fractions in dogs with and without perfusion defects. Methods: Sixteen dogs were subjected to either chronic occlusion of the circumflex artery (group I, no perfusion defect) or acute occlusion of the anterior descending coronary artery (group II, perfusion defect). Both groups underwent serial MRI and SPECT. Results: QGS was very reproducible using the automated program (r = 0.99997). Correlation between left ventricular ejection fraction (LVEF) at 15 and 45 min was poor after the low-dose injection (r = 0.54; SE = 9%) and only fair after the high-dose injection (r = 0.77; SE = 5%). Correlation was poor in the presence of significant background activity (r = 0.36; SE = 12%). Correlation between QGS left ventricular volumes and MRI was good for group I (end-diastolic volume, r = 0.86; end-systolic volume, r = 0.81) and only fair for group II (end-diastolic volume, r = 0.66; end-systolic volume, r = 0.69). The overall LVEF correlation between QGS and MRI was poor (r = 0.51). QGS LVEF (mean ± SD, 42% ± 3%) overestimated MRI LVEF (29% ± 2%). Conclusion: QGS provides a highly reproducible estimate of LVEF. However, QGS is affected by changes in background activity, time of imaging, and injected dose. In the presence of perfusion defects, QGS overestimated volume relative to MRI. The correlation between QGS- and MRI-derived LVEF was poor in this canine model.

Key Words: MRI • left ventricular ejection fraction • electrocardiography-gated SPECT

This article has been cited by other articles:

				T. F. Heston and D. M. Sigg Quantifying Transient Ischemic Dilation Using Gated SPECT J. Nucl. Med., December 1, 2005; 46(12): 1990 - 1996. [Abstract] [Full Text] [PDF]

				A. Manrique, A. Hitzel, D. Brasse, and P. Vera Effect of Perfusion Pattern and Imaging Sequence on Gated Perfusion SPECT Evaluation of Myocardial Stunning J. Nucl. Med., January 1, 2005; 46(1): 176 - 183. [Abstract] [Full Text] [PDF]

				V. Go, M. R. Bhatt, and R. C. Hendel The Diagnostic and Prognostic Value of ECG-Gated SPECT Myocardial Perfusion Imaging J. Nucl. Med., May 1, 2004; 45(5): 912 - 921. [Abstract] [Full Text] [PDF]

				W. J. Kang, D. S. Lee, J. C. Paeng, K.-B. Kim, J.-K. Chung, and M. C. Lee Prognostic Value of Rest 201Tl-Dipyridamole Stress 99mTc-Sestamibi Gated SPECT for Predicting Patient-Based Clinical Outcomes After Bypass Surgery in Patients with Ischemic Left Ventricular Dysfunction J. Nucl. Med., November 1, 2003; 44(11): 1735 - 1740. [Abstract] [Full Text] [PDF]

				A. Khorsand, S. Graf, H. Frank, K. Kletter, H. Sochor, G. Maurer, E. Schuster, S. Globits, R. Dudczak, and G. Porenta Model-Based Analysis of Electrocardiography-Gated Cardiac 18F-FDG PET Images to Assess Left Ventricular Geometry and Contractile Function J. Nucl. Med., November 1, 2003; 44(11): 1741 - 1746. [Abstract] [Full Text] [PDF]

				J. P. A. Ioannidis, T. A. Trikalinos, and P. G. Danias Electrocardiogram-gated single-photonemission computed tomography versus cardiacmagnetic resonance imaging for the assessmentof left ventricular volumes and ejection fraction: A meta-analysis J. Am. Coll. Cardiol., June 19, 2002; 39(12): 2059 - 2068. [Abstract] [Full Text] [PDF]

				K. Nakajima, T. Higuchi, J. Taki, M. Kawano, and N. Tonami Accuracy of Ventricular Volume and Ejection Fraction Measured by Gated Myocardial SPECT: Comparison of 4 Software Programs J. Nucl. Med., October 1, 2001; 42(10): 1571 - 1578. [Abstract] [Full Text] [PDF]

				E. Itti, J. Rosso, H. Hammami, S. Benayoun, J.-P. Thirion, and M. Meignan Myocardial Tracking, A New Method to Calculate Ejection Fraction with Gated SPECT: Validation with 201Tl Versus Planar Angiography J. Nucl. Med., June 1, 2001; 42(6): 845 - 852. [Abstract] [Full Text] [PDF]

				G. Germano, D. S. Berman, A. J. Sinusas, and F. J. Th. Wackers Quantitative Gated SPECT J. Nucl. Med., March 1, 2001; 42(3): 528 - 529. [Full Text]