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On-Line Measurement of Exhaled [¹¹C]CO₂ During PET

Medical Research Council Cyclotron Unit, Hammersmith Hospital, Imperial College School of Medicine, London, United Kingdom

Correspondence: For correspondence or reprints contact: Roger N. Gunn, PhD, Medical Research Council Cyclotron Unit, Hammersmith Hospital, Imperial College School of Medicine, DuCane Rd., London W12 0NN, UK.

ABSTRACT

The purpose of this study was to develop and evaluate a system for the continuous on-line measurement of expired ^1lCO₂ during ¹¹C PET studies. Methods: A detector system was developed that allowed continuous sampling of expired air during PET. Healthy volunteers (n = 4) underwent PET with [¹¹C]CO₂ during which expired air, tomographic tissue activity, and blood data were collected. Trie measured expired-air ¹¹CO₂ radioactivity time courses were filtered, and an envelope was extracted and compared with the time course of ¹¹CO₂/H¹¹CO₃^– in blood. Results: Good agreement was found between the shapes of the expired-air envelope and the time course in blood, enabling quantitative calibration against discrete blood samples. Conclusion: A system for the continuous monitoring of expired radioactivity during PET has been developed and evaluated with [¹¹C]CO₂. This monitoring enables the quantitative continuous measurement of ¹¹CO₂/H¹¹CO₃^– in blood.

Key Words: [¹¹C]CO₂ • PET • expired air • metabolites

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