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Biodistribution, Dosimetry, and Safety of Myocardial Perfusion Imaging Agent ^99mTcN-NOET in Healthy Volunteers

Faculté de Médecine, Université de Grenoble, Grenoble
Clinique Cardiologique and Service de Médecine Nucléaire, Center Hospitalier Universitaire, Grenoble
Cis Biointernational, Gifsur Yvette, France

Correspondence: For correspondence or reprints contact: Daniel Fagret, MD, Laboratoire d'Etudes de Radiopharmaceutiques, LER-ESA CNRS 5077-LRC CEA 10, Faculté de Médecine, Université de Grenoble, La Tronche 38700, France.

ABSTRACT

^99mTcN-NOET (bis[N-ethoxy,N-ethyl]dithiocarbamato nitrido technetium (V)) has been proposed for myocardial perfusion imaging. Biodistribution, safety, and dosimetry were studied in 10 healthy volunteers (5 at rest and 5 during exercise). Methods: Biodistribution was studied by acquiring dynamic images up to 60 min after injection and whole-body images up to 24 h after injection. The MIRDOSE3 analysis program was used for radiation dosimetry calculations. Results: Safety parameters measured to 48 h after injection revealed no clinically significant changes. Cardiac uptake of ^99mTcN-NOET was high (2.9–3%), with biologic half-life of 210–257 min on average. Lung uptake of ^99mTcN-NOET was higher (10–20%) but, on average, biologic half-life was shorter (1–77 min). Clearance from the blood was rapid (5% by 5 min). Radiation dosimetry calculations indicated an effective absorbed dose of 5.11 x 10^–3 mSv/MBq at rest and 5.38 x 10^–3 mSv/MBq after exercise. Conclusion: ^99mTcN-NOET exhibits high cardiac uptake and an estimated effective absorbed dose comparable with that of the other ^99mTc-labeled compounds used in myocardial perfusion imaging.

Key Words: ^99mTcN-NOET • myocardial perfusion agent • biodistribution • dosimetry

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