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Biodistribution and Absorbed Radiation Dose Estimates of ^99mTc-Labeled Dimercaptopropionyl Human Serum Albumin

Departments of Medical Physics and Nuclear Medicine, University of the Orange Free State, Bloemfontein, South Africa
Department of Radiopharmacy, University of Leuven, Leuven, Belgium

Correspondence: For correspondence or reprints contact: Andries van Aswegen, PhD, Department of Medical Physics, University of the Orange Free State, P.O. Box 339, 9300 Bloemfontein, South Africa.

ABSTRACT

The use of ^99mTc-labeled red blood cells (RBC) for the evaluation of left ventricular function using equilibrium-gated blood-pool imaging suffers from several problems and potential risks. In this study, we estimated the absorbed radiation dose of ^99mTc-labeled dimercaptopropionyl human serum albumin (DMP-HSA) as a potential alternative to ^99mTc-RBC. Methods: After the administration of ^99mTc-DMP-HSA, whole-body imaging was performed up to 48 h after injection in five volunteers. The heart contents, liver and remainder of the body were used as source organs. Multicompartment modeling of the biodistribution was performed and absorbed radiation dose estimates for ^99mTc-DMP-HSA were obtained using the Medical Internal Radiation Dose (MIRD) calculation. Results: Residence times of 0.62 and 0.43 h were obtained for the heart contents and liver, respectively. Radiation dose estimates yielded an effective dose of 0.0055 mSv/MBq. Conclusion: ^99mTc-DMP-HSA yielded absorbed radiation doses comparable with those of ^99mTc-RBC. Therefore, the radiation properties of ^99mTc-DMP-HSA are such that it can be used for clinical diagnostic studies.

Key Words: ^99mTc blood-pool labeling • dosimetry • Medical Internal Radiation Dose • ^99mTc-labeled dimercaptopropionyl human serum albumin