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A Radionuclide Therapy Treatment Planning and Dose Estimation System

Department of Radioimmunotherapy, Divisions of Radiology and Radiation Oncology, City of Hope National Medical Center, Duarte, California

Correspondence: For correspondence or reprints contact: Lawrence E. Williams, PhD, Division of Radiology, City of Hope National Medical Center, Duarte, CA 91010.

ABSTRACT

An object-oriented software system is described for estimating internal emitter absorbed doses using a set of computer modules operating within a personal computer environment. The system is called the Radionuclide Treatment Planning and Absorbed Dose Estimation System (RTDS). It is intended for radioimmunotherapy applications, although other forms of internal emitter therapy may also be considered. Methods: Four software modules interact through a database backend. Clinical, demographic and image data are directly entered into the database. Modules include those devoted to clinical imaging (nuclear, CT and MR), activity determination, organ compartmental modeling and absorbed dose estimation. Results: Both standard phantom (Medical Internal Radiation Dose [MIRD]) and patient-specific absorbed doses are estimated. All modules interact with the database backend so that changes in one process do not influence other operations. Results of the modular operations are written to the database as computations are completed. Dosevolume histograms are an intrinsic part of the output for patient-specific absorbed dose estimates. A sample dose estimate for a potential ⁹⁰Y monoclonal antibody is described. Conclusion: A four-module software system has been implemented to estimate MIRD phantom and patient-specific absorbed doses. Computations of the doses and their statistical distribution for a pure beta emitter such as ⁹⁰Y take approximately 1 min on a 300 MHz personal computer.

Key Words: radioimmunotherapy • radionuclide treatment planning • absorbed dose estimation system

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