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Relative ^99mTc-MAG3 Renal Uptake: Reproducibility and Accuracy

Department of Radioisotopes, Centre Hospitalo-Universitaire Saint-Pierre and Akademisch Ziekenhuis, Free Universities of Brussels, Belgium

Correspondence: For correspondence or reprints contact: Amy Piepsz, MD, Department of Radioisotopes, CHU St. Pierre, 322 Rue Haute, B-1000 Brussels, Belgium.

ABSTRACT

The aim of this study was to estimate the reproducibility and accuracy of ^99mTc-mercaptoacetyltriglycine (MAG3) relative percentage uptake. Methods: Reproducibility was evaluated on healthy volunteers who were submitted twice to a ^99mTc-MAG3 renographic study, which used different uptake algorithms, different background corrections and different time intervals. Accuracy was evaluated in a group of patients with symmetrical or asymmetrical relative renal function, who underwent both ^99mTc-dimercaptosuccinic acid (DMSA) and ^99mTc-MAG3 studies, using the DMSA relative percentage uptake as a reference. Results and Conclusion: The methods that combined the best reproducibility and accuracy for estimating ^99mTc-MAG3 left-to-right uptake ratio were the integral method, with subrenal or perirenal background correction, and the Patlak-Rutland plot. The use of the integral method without background correction introduced a systematic bias, whereas the slope method resulted in high variability. Therefore these methods cannot be recommended.

Key Words: ^99mTc-mercaptoacetyltriglycine • ^99mTc-dimercaptosuccinic acid • relative renal uptake • reproducibility • accuracy