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Double-Phase ^99mTc-Sestamibi Scintimammography and Trans-Scan in Diagnosing Breast Cancer

Departments of Nuclear Medicine, Urology, Surgery and Pathology, Hasharon Hospital, Rabin Medical Center, Petah Tikva
Department of Radiology, Bnei-Zyon Hospital, Haifa, Israel

Correspondence: For correspondence or reprints contact: Moshe Melloul, MD, Department of Nuclear Medicine, Hasharon Hospital, 7, Keren-Kayemet St., PO Box 121, Petah-Tikva, 49372, Israel.

ABSTRACT

The goal of our study was to assess the value of both scintimammography with ^99mTc-sestamibi (SMM) and trans-scan (T-scan) in detecting breast cancer. Methods: A total of 121 women were evaluated by palpation, mammography, SMM and T-scan. SMM was performed in the prone, breast dependent position. Immediate and delayed views (double-phase) were obtained. T-scan is a new breast imaging method that maps noninvasively the distribution of tissue electrical impedance and capacitance. Results: SMM had 88.9% sensitivity, 88.4% specificity and 88.4% accuracy in detecting breast cancer. SMM had 100% sensitivity in detecting breast tumors >1 cm and only 66% sensitivity in detecting tumors <1 cm. T-scan had 72.2% sensitivity and 67% specificity in detecting breast cancer. It detected one more breast cancer than SMM, at the expense of 27 additional false-positive results. Conclusion: Double-phase SMM was sensitive and specific in detecting breast cancer. This method may reduce the rate of negative breast biopsies in tumors >1 cm. T-scan was only moderately accurate in detecting breast cancer. Its addition to SMM did not improve significantly the rate of breast cancer detection. However, because of its complete noninvasiveness, large-scale applicability and low cost, T-scan deserves further refining.

Key Words: ^99mTc-sestamibi scintimammography • breast cancer • trans-scan

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