HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Satoh, A. Articles by Tsujihata, M. Search for Related Content PubMed PubMed Citation Articles by Satoh, A. Articles by Tsujihata, M.

Loss of ¹²³I-MIBG Uptake by the Heart in Parkinson's Disease: Assessment of Cardiac Sympathetic Denervation and Diagnostic Value

Division of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan

Correspondence: For correspondence or reprints contact: Akira Satoh, MD, Division of Neurology, Nagasaki Kita Hospital, 4-61 Nameshi 5-chome, Nagasaki 852, Japan.

ABSTRACT

Myocardial imaging with ¹²³I-metaiodobenzylguanidine (MIBG) was performed on 35 patients with Parkinson's disease and 24 control subjects to evaluate cardiac sympathetic function in patients with Parkinson's disease, verify this phenomenon and examine whether myocardial MIBG uptake and clearance are correlated with the clinical severity of Parkinson's disease. Methods: We studied 35 patients with Parkinson's disease and 24 control subjects with other central nervous system diseases. The latter group consisted of 12 subjects with other neurodegenerative disorders (4 with spinocerebellar degeneration, 2 with amyotrophic lateral sclerosis, 3 with progressive supranuclear palsy and 3 with corticobasal degeneration and 12 patients with cerebral infarction (CI), 6 with vascular parkinsonism and 6 without it. Early and delayed images of the anterior view were obtained 15 min and 4 h after injection of ¹²³I-MIBG, respectively. MIBG uptake was quantified by calculating a heart-to-mediastinum count (H/M) ratio. Results: The H/M ratio was markedly reduced in the patients with Parkinson's disease (II to V on the Hoehn and Yahr scale) compared with the control subjects. None of the subjects with neurodegenerative diseases showed a marked decrease in myocardial MIBG uptake nor did any subject with CI. Conclusion: Our findings indicate that, in Parkinson's disease, a reduction in myocardial MIBG uptake is a very common, specific phenomenon that can be used to detect cardiac autonomic dysfunction to diagnose Parkinson's disease, particularly in patients without typical signs and symptoms.

Key Words: Parkinson's disease • metaiodobenzylguanidine • autonomic function • sympathetic nervous system

This article has been cited by other articles:

				A. Lipp, P. Sandroni, J. E. Ahlskog, R. D. Fealey, K. Kimpinski, V. Iodice, T. L. Gehrking, S. D. Weigand, D. M. Sletten, J. A. Gehrking, et al. Prospective Differentiation of Multiple System Atrophy From Parkinson Disease, With and Without Autonomic Failure Arch Neurol, June 1, 2009; 66(6): 742 - 750. [Abstract] [Full Text] [PDF]

				H. Oka, M. Yoshioka, M. Morita, K. Onouchi, M. Suzuki, Y. Ito, T. Hirai, S. Mochio, and K. Inoue Reduced cardiac 123I-MIBG uptake reflects cardiac sympathetic dysfunction in Lewy body disease Neurology, October 2, 2007; 69(14): 1460 - 1465. [Abstract] [Full Text] [PDF]

				D. M. Raffel, R. A. Koeppe, R. Little, C.-N. Wang, S. Liu, L. Junck, M. Heumann, and S. Gilman PET Measurement of Cardiac and Nigrostriatal Denervation in Parkinsonian Syndromes J. Nucl. Med., November 1, 2006; 47(11): 1769 - 1777. [Abstract] [Full Text] [PDF]

				H Nagayama, M Hamamoto, M Ueda, J Nagashima, and Y Katayama Reliability of MIBG myocardial scintigraphy in the diagnosis of Parkinson's disease J. Neurol. Neurosurg. Psychiatry, February 1, 2005; 76(2): 249 - 251. [Abstract] [Full Text] [PDF]

				D. S. Goldstein, S.-T. Li, C. Holmes, and K. Bankiewicz Sympathetic Innervation in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Primate Model of Parkinson's Disease J. Pharmacol. Exp. Ther., September 1, 2003; 306(3): 855 - 860. [Abstract] [Full Text] [PDF]

				D. S. Goldstein, S. Pechnik, C. Holmes, B. Eldadah, and Y. Sharabi Association Between Supine Hypertension and Orthostatic Hypotension in Autonomic Failure Hypertension, August 1, 2003; 42(2): 136 - 142. [Abstract] [Full Text] [PDF]

				K Hamada, M Hirayama, H Watanabe, R Kobayashi, H Ito, T Ieda, Y Koike, and G Sobue Onset age and severity of motor impairment are associated with reduction of myocardial 123I-MIBG uptake in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, April 1, 2003; 74(4): 423 - 426. [Abstract] [Full Text] [PDF]

				D. S. Goldstein, D. Robertson, M. Esler, S. E. Straus, and G. Eisenhofer Dysautonomias: Clinical Disorders of the Autonomic Nervous System Ann Intern Med, November 5, 2002; 137(9): 753 - 763. [Abstract] [Full Text] [PDF]

				D. S. Goldstein, C. S. Holmes, R. Dendi, S. R. Bruce, and S.-T. Li Orthostatic hypotension from sympathetic denervation in Parkinson's disease Neurology, April 23, 2002; 58(8): 1247 - 1255. [Abstract] [Full Text] [PDF]

				P. A. R. de Milliano, B. L. F. van Eck-Smit, A. C. de Groot, and K. I. Lie Metoprolol-Induced Changes in Myocardial 123I-Metaiodobenzylguanidine Uptake in Parkinson's Disease Circulation, November 14, 2000; 102(20): 2553 - 2554. [Full Text] [PDF]

				D. S. Goldstein, C. Holmes, S.-T. Li, S. Bruce, L. V. Metman, and R. O. Cannon III Cardiac Sympathetic Denervation in Parkinson Disease Ann Intern Med, September 5, 2000; 133(5): 338 - 347. [Abstract] [Full Text] [PDF]

				M. Yoshita and S. Braune Cardiac uptake of [123I]MIBG separates PD from multiple system atrophy Neurology, May 9, 2000; 54(9): 1877 - 1878. [Full Text] [PDF]