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Reproducibility Studies with ¹¹C-DTBZ, a Monoamine Vesicular Transporter Inhibitor in Healthy Human Subjects

TRIUMF and Neurodegenerative Disorders Center, University of British Columbia, Vancouver, British Columbia
Department of Medical Physics, University of Wisconsin, Madison, Wisconsin

Correspondence: For correspondence or reprints contact: Grace Lap-Yu Chan, PhD, Rm. G343, ACU, PET, Vancouver Hospital and Health Sciences Center, UBC Site, 2211 Westbrook Mall, Vancouver, BC, Canada V6T 2B5.

ABSTRACT

The reproducibility of (±)--[¹¹C] dihydrotetrabenazine (DTBZ) measures in PET was studied in 10 healthy human subjects, aged 22–76 y. Methods: The scan-to-scan variation of several measures used in PET data analysis was determined, including the radioactivity ratio (target-to-reference), plasma-input Logan total distribution volume (DV), plasma-input Logan and tissue-input Logan B_max/K_d values. Results: The radioactivity ratios, plasma-input B_max/K_d and tissue-input B_max/K_d all have higher reliability than plasma-input total DV values. In addition, measures using the occipital cortex as the reference region have higher reliability than the same measures using the cerebellum as the reference region. Conclusion: Our results show that DTBZ is a reliable PET tracer that provides reproducible in vivo measurement of striatal vesicular monoamine transporter density. In the selection of reference regions for DTBZ PET data analysis, caution must be exercised in circumstances when DTBZ binding in the occipital cortex or the cerebellum may be altered.

Key Words: [¹¹C]dihydrotetrabenazine • PET imaging • vesicular monoamine transporter 2

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