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Division of Tracer Kinetics, Biomedical Research Center, The First Department of Medicine, Osaka University Medical School, Osaka, Japan
Correspondence: For correspondence or reprints contact: Tsunehiko Nishimura, MD, PhD, Division of Tracer Kinetics, Biomedical Research Center, Osaka University Medical School, D9, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
ABSTRACT
We compared the left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fraction (LVEF) as calculated by Cedars automated quantitative gated SPECT (QGS) to those determined by first-pass radionuclide angiography (FPRNA) and contrast left ventriculography (LVG) in a group of 21 patients (mean age 61.4 ± 9.2 y). Methods: A total of 740 MBq 99mTc-tetrofosmin was administered rapidly into the right cubital vein at rest, and FPRNAwas performed using a multicrystal gamma camera. One hour after injection, QGS was performed with a temporal resolution of 10 frames per R-R interval. LVG was performed within 2 wk. Results: The EDV, ESV and LVEF calculated by QGS were highly reproducible (intraobserver, r = 0.99, r = 0.99 and r = 0.99, respectively; interobserver, r = 0.99, r = 0.99 and r = 0.99, respectively; P < 0.01) and were more consistent than those determined by FPRNA (intraobserver, r = 0.97, r = 0.95 and r = 0.93, respectively; interobserver, r = 0.86, r = 0.96 and r = 0.91, respectively; P < 0.01). There was a good correlation between EDV, ESV and LVEF by FPRNA and those by LVG (r = 0.61, r = 0.72 and r = 0.91, respectively; P < 0.01), and there was an excellent correlation between QGS and LVG (r = 0.73, r = 0.83 and r = 0.87, respectively; P < 0.01). The mean EDV by QGS (100 ± 11.3 mL) was significantly lower than by FPRNA (132± 16.8 mL) or LVG (130± 8.1 mL), and the mean ESV by QGS (53.8 ± 9.3 mL) was lower than by FPRNA (73.0 ± 13.3 mL) . Ejection fraction values were highest by LVG (57.1% ± 3.2%), then QGS (51.8% ± 3.0%) and FPRNA (48.9% ± 2.4%). Conclusion: QGS gave more reproducible results than FPRNA. LV volumes and LVEF calculated by QGS correlated well to those by LVG.
Key Words: 99mTc-tetrofosmin • gated SPECT • first-pass radionuclide angiography • contrast left ventriculography • automatic ejection fraction quantitation
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