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Quantitative SPECT Uptake of ^99mTc-Dimercaptosuccinic Acid by the Kidneys in Children

Department of Nuclear Medicine, Bnai Zion Medical Center and Rebecca Sieff Government Hospital, Safed
The Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Correspondence: For correspondence or reprints contact: David Groshar, MD, Department of Nuclear Medicine, Bnai Zion Medical Center, 47 Golomb St., P.O. Box 4940, Haifa, Israel, 31048.

ABSTRACT

The normal range of values for quantitative SPECT of ^99mTc-dimercaptosuccinic acid (DMSA) uptake by the kidneys in children was studied. Methods: Renal functioning volume, percentage of injected dose per cubic centimeter of renal tissue (%ID/cm³) and individual kidney uptake of 270 kidneys performed on 135 children, aged 2 wk–15 y, provided the basic data for this study. The accrual was part of the work-up of children with urinary tract infection where no structural or functional abnormalities of the renal tract could be established. Children were grouped according to age intervals, and a distribution chart was obtained with 2 SD above and below the mean of the values obtained for volume (%ID/cm³) and kidney uptake in each age group. Results: A significant correlation was found between age and functional volume (r = 0.90; 95% confidence interval [CI], 0.88–0.92; P = 0.000), and a significant inverse correlation was found between age and %ID/cm³ (r = –0.86; 95% CI, –0.88 to –0.82; P = 0.000). No statistically significant correlation was found between age and kidney uptake (r = –0.20; 95% CI, –0.32 to –0.09; P = 0.001). Conclusion: It seems that the normal maturational changes in renal function observed in infants and newborns do not affect the kidney uptake of ^99mTc-DMSA. Thus, quantitation of ^99mTc-DMSA uptake by the kidneys can be used to assess changes in the individual renal function over time in this age group.

Key Words: dimercaptosuccinic acid • SPECT • renal function • pediatrics

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