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Recovery of Hepatic Asialoglycoprotein Receptors After Major Hepatic Resection

Departments of Surgery and Radiology, Cancer Institute Hospital, Tokyo, Japan
Department of Radiology, University of California-Davis Medical Center, Sacramento, California

Correspondence: For correspondence or reprints contact: Norihiro Kokudo, MD, Department of Surgery, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo, Japan 170-8455.

ABSTRACT

Although morphological restoration of the hepatic mass after partial hepatectomy has been well studied, fewer reports have appeared on the change of functional hepatic capacity during liver regeneration. Asialoglycoprotein receptor (ASGP-R) is a hepatic cell surface receptor specific for galactose-terminated glycoprotein. Kinetic modeling of ^99mTc-labeled diethylenetriamine pentaacetic acid-galactosyl-human serum albumin (TcGSA) time-activity data yields estimates of ASGP-R concentration [R]₀ and amount R₀, which are directly related to functional liver mass. We have investigated the changes in ASGP-R status as well as liver volume in regenerating human liver after major hepatic resection. Methods: Twenty-two patients (18 noncirrhotic, 4 cirrhotic) had a TcGSA study before and 3 wk after major hepatic resection, with a mean hepatic parenchymal resection rate of 36.0%. Results: [R]₀ was significantly decreased from 0.683 ± 0.024 µmol/L to 0.565 ± 0.032 µmol/L (P < 0.001) after resection. The decrease in [R]₀ was more prominent in cirrhotic patients. Recovery of ASGP-R was observed as a significantly increased R₀ 3 wk after the operation. Subsequent (long-term) restoration of ASGP-R appeared to be slower when compared with the volume restoration. Conclusion: ASGP-R concentration of the liver significantly decreased after major hepatic resection. Subsequent recovery of ASGP-R amount was shown by TcGSA study. By estimating hepatic functional reserve expressed by ASGP-R amount and concentration, one may detect a delayed or impaired liver regeneration with higher sensitivity.

Key Words: ^99mTcGSA • asialoglycoprotein receptor • hepatic resection • liver regeneration

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				E. V. Groman and C. P. Reinhardt Hepatocyte Asialoglycoprotein Receptor Assay Using Stable Isotopes and Neutron Activation Analysis Clin. Chem., September 1, 2000; 46(9): 1519 - 1521. [Full Text] [PDF]