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Decreased Benzodiazepine Receptor Binding in Machado-Joseph Disease

Division of Nuclear Medicine and Department of Radiology, Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume-City
Department of Neurology, National Chikugo Hospital, Fukuoka
Biomedical Imaging Research Center, Fukui Medical School, Fukui
Nihon Medi-Physics Co., Ltd., Hyogo, Japan

Correspondence: For correspondence or reprints contact: Masatoshi Ishibashi, MD, Department of Radiology and Division of Nuclear Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume City, Fukuoka, 830-001 1, Japan.

ABSTRACT

Benzodiazepine receptor binding was assessed in four Japanese men with Machado-Joseph disease. Methods: The distribution of benzodiazepine receptors was measured by radionuclide imaging (SPECT)after intravenous administration of ¹²³I-iomazenil (Ro 160154). Results:SPECT demonstrated decreased binding through out the cerebral cortex and cerebellum in all patients. Binding potential (receptor concentration x affinity)was diffusely decreased in cerebral cortex, thalamus, striatum and cerebellum compared with control subjects, suggesting that GABAergic function may be decreased globally in these patients. Cerebral blood flow was largely normal, and no cerebral cortical atrophy was evident on MRI. Conclusion: Iodine-123-iomazenil SPECT may become a potent method for detecting impairment of the cerebral cortex even before brain perfusion SPECT or MRI can reveal early abnormalities.

Key Words: iodine-123-iomazenil • benzodiazepine receptor • Machado-Joseph disease • SPECT

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				E. C. S. C. Etchebehere, F. Cendes, I. Lopes-Cendes, J. A. Pereira, M. C. L. Lima, C. R. Sansana, C. A. M. Silva, M. F. A. G. Camargo, A. O. Santos, C. D. Ramos, et al. Brain Single-Photon Emission Computed Tomography and Magnetic Resonance Imaging in Machado-Joseph Disease Arch Neurol, August 1, 2001; 58(8): 1257 - 1263. [Abstract] [Full Text] [PDF]