HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hara, T. Articles by Kishi, H. Search for Related Content PubMed PubMed Citation Articles by Hara, T. Articles by Kishi, H.

PET Imaging of Prostate Cancer Using Carbon-11-Choline

Departments of Radiology and Urology, International Medical Center of Japan, Tokyo, Japan

Correspondence: For correspondence or reprints contact: Toshihiko Hara, MD, Department of Radiology, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162, Japan.

ABSTRACT

Prostate cancer is difficult to visualize using current techniques. Recently, ³¹P magnetic resonance spectroscopy has revealed that the tumor, in general, is characterized by an increased uptake of choline into the cell to meet increased synthesis of phosphatidylcholine, an important cell membrane phospholipid. We succeeded in using ¹¹C-choline to visualize prostate cancer and its local metastasis in PET. Methods: PET was performed on 10 prostate cancer patients from the level of pelvis to the lower abdomen. After transmission scanning, 370MBq ¹¹C-choline were injected intravenously. The emission scan was performed 5–15 min postinjection. Finally, PET images were displayed so that each pixel was painted by a specified color representing the degree of the standardized uptake value (SUV). The ¹¹C-choline image was compared with the ¹⁸F-fluorodeoxyglucose (FDG) image obtained from the same patient. Results: Imaging of prostate cancer and its local metastasis was difficult when ¹⁸F-FDG was used because, within the pelvis, the areas of high uptake were concealed by the overwhelmingly abundant radioactivity in urine (in ureters arid bladder). By contrast, it was easy when ¹¹C-choline was used because the urinary activity was negligible and tumor uptake was marked. The radioactivity concentration ¹¹C-choline in prostate cancer and metastatic sites was at an SUV of more than three in most cases. The SUV of ¹⁸F-FDG was considerably lower than that of ¹¹C-choline. Conclusion: Prostate cancer and its local metastasis were visualized clearly in PET using ¹¹C-choline.

Key Words: PET • carbon-11-choline • prostate cancer

This article has been cited by other articles:

				Y. Yamamoto, Y. Nishiyama, R. Kameyama, K. Okano, H. Kashiwagi, A. Deguchi, M. Kaji, and M. Ohkawa Detection of Hepatocellular Carcinoma Using 11C-Choline PET: Comparison with 18F-FDG PET J. Nucl. Med., August 1, 2008; 49(8): 1245 - 1248. [Abstract] [Full Text] [PDF]

				C. Plathow and W. A. Weber Tumor Cell Metabolism Imaging J. Nucl. Med., June 1, 2008; 49(Suppl_2): 43S - 63S. [Abstract] [Full Text] [PDF]

				D. J. A. Margolis, J. M. Hoffman, R. J. Herfkens, R. B. Jeffrey, A. Quon, and S. S. Gambhir Molecular Imaging Techniques in Body Imaging Radiology, November 1, 2007; 245(2): 333 - 356. [Abstract] [Full Text] [PDF]

				T. Terauchi, U. Tateishi, T. Maeda, D. Kanou, H. Daisaki, Y. Moriya, N. Moriyama, and T. Kakizoe A Case of Colon Cancer Detected by Carbon-11 Choline Positron Emission Tomography/Computed Tomography: An Initial Report Jpn. J. Clin. Oncol., October 1, 2007; 37(10): 797 - 800. [Abstract] [Full Text] [PDF]

				V. Kundra, P. M. Silverman, S. F. Matin, and H. Choi Imaging in Oncology from The University of Texas M. D. Anderson Cancer Center: Diagnosis, Staging, and Surveillance of Prostate Cancer Am. J. Roentgenol., October 1, 2007; 189(4): 830 - 844. [Abstract] [Full Text] [PDF]

				C. Testa, R. Schiavina, R. Lodi, E. Salizzoni, B. Corti, M. Farsad, J. Kurhanewicz, F. Manferrari, E. Brunocilla, C. Tonon, et al. Prostate Cancer: Sextant Localization with MR Imaging, MR Spectroscopy, and 11C-Choline PET/CT Radiology, September 1, 2007; 244(3): 797 - 806. [Abstract] [Full Text] [PDF]

				S. Oka, R. Hattori, F. Kurosaki, M. Toyama, L. A. Williams, W. Yu, J. R. Votaw, Y. Yoshida, M. M. Goodman, and O. Ito A Preliminary Study of Anti-1-Amino-3-18F-Fluorocyclobutyl-1-Carboxylic Acid for the Detection of Prostate Cancer J. Nucl. Med., January 1, 2007; 48(1): 46 - 55. [Abstract] [Full Text] [PDF]

				F. Peng, X. Lu, J. Janisse, O. Muzik, and A. F. Shields PET of Human Prostate Cancer Xenografts in Mice with Increased Uptake of 64CuCl2 J. Nucl. Med., October 1, 2006; 47(10): 1649 - 1652. [Abstract] [Full Text] [PDF]

				T. Maeda, U. Tateishi, M. Komiyama, H. Fujimoto, S.-I. Watanabe, T. Terauchi, N. Moriyama, Y. Arai, K. Sugimura, and T. Kakizoe Distant Metastasis of Prostate Cancer: Early Detection of Recurrent Tumor with Dual-Phase Carbon-11 Choline Positron Emission Tomography/Computed Tomography in Two Cases Jpn. J. Clin. Oncol., September 1, 2006; 36(9): 598 - 601. [Abstract] [Full Text] [PDF]

				S. N. Reske, N. M. Blumstein, B. Neumaier, H.-W. Gottfried, F. Finsterbusch, D. Kocot, P. Moller, G. Glatting, and S. Perner Imaging Prostate Cancer with 11C-Choline PET/CT J. Nucl. Med., August 1, 2006; 47(8): 1249 - 1254. [Abstract] [Full Text] [PDF]

				M. Picchio, U. Treiber, A. J. Beer, S. Metz, P. Bossner, H. van Randenborgh, R. Paul, G. Weirich, M. Souvatzoglou, R. Hartung, et al. Value of 11C-Choline PET and Contrast-Enhanced CT for Staging of Bladder Cancer: Correlation with Histopathologic Findings J. Nucl. Med., June 1, 2006; 47(6): 938 - 944. [Abstract] [Full Text] [PDF]

				S. A. Kwee, H. Wei, I. Sesterhenn, D. Yun, and M. N. Coel Localization of Primary Prostate Cancer with Dual-Phase 18F-Fluorocholine PET J. Nucl. Med., February 1, 2006; 47(2): 262 - 269. [Abstract] [Full Text] [PDF]

				A. van Waarde, P. L. Jager, K. Ishiwata, R. A. Dierckx, and P. H. Elsinga Comparison of Sigma-Ligands and Metabolic PET Tracers for Differentiating Tumor from Inflammation J. Nucl. Med., January 1, 2006; 47(1): 150 - 154. [Abstract] [Full Text] [PDF]

				N. Pandit-Taskar Oncologic Imaging in Gynecologic Malignancies J. Nucl. Med., November 1, 2005; 46(11): 1842 - 1850. [Abstract] [Full Text] [PDF]

				M. Farsad, R. Schiavina, P. Castellucci, C. Nanni, B. Corti, G. Martorana, R. Canini, W. Grigioni, S. Boschi, M. Marengo, et al. Detection and Localization of Prostate Cancer: Correlation of 11C-Choline PET/CT with Histopathologic Step-Section Analysis J. Nucl. Med., October 1, 2005; 46(10): 1642 - 1649. [Abstract] [Full Text] [PDF]

				N. Spaeth, M. T. Wyss, B. Weber, S. Scheidegger, A. Lutz, J. Verwey, I. Radovanovic, J. Pahnke, D. Wild, G. Westera, et al. Uptake of 18F-Fluorocholine, 18F-Fluoroethyl-L-Tyrosine, and 18F-FDG in Acute Cerebral Radiation Injury in the Rat: Implications for Separation of Radiation Necrosis from Tumor Recurrence J. Nucl. Med., November 1, 2004; 45(11): 1931 - 1938. [Abstract] [Full Text] [PDF]

				X. Chen, R. Park, Y. Hou, M. Tohme, A. H. Shahinian, J. R. Bading, and P. S. Conti microPET and Autoradiographic Imaging of GRP Receptor Expression with 64Cu-DOTA-[Lys3]Bombesin in Human Prostate Adenocarcinoma Xenografts J. Nucl. Med., August 1, 2004; 45(8): 1390 - 1397. [Abstract] [Full Text] [PDF]

				E. M. Rohren, T. G. Turkington, and R. E. Coleman Clinical Applications of PET in Oncology Radiology, May 1, 2004; 231(2): 305 - 332. [Abstract] [Full Text] [PDF]

				T. Hara, N. Kosaka, T. Suzuki, K. Kudo, and H. Niino Uptake Rates of 18F-Fluorodeoxyglucose and 11C-Choline in Lung Cancer and Pulmonary Tuberculosis: A Positron Emission Tomography Study Chest, September 1, 2003; 124(3): 893 - 901. [Abstract] [Full Text] [PDF]

				T. Torizuka, T. Kanno, M. Futatsubashi, H. Okada, E. Yoshikawa, F. Nakamura, M. Takekuma, M. Maeda, and Y. Ouchi Imaging of Gynecologic Tumors: Comparison of 11C-Choline PET with 18F-FDG PET J. Nucl. Med., July 1, 2003; 44(7): 1051 - 1056. [Abstract] [Full Text] [PDF]

				N. Oyama, T. R. Miller, F. Dehdashti, B. A. Siegel, K. C. Fischer, J. M. Michalski, A. S. Kibel, G. L. Andriole, J. Picus, and M. J. Welch 11C-Acetate PET Imaging of Prostate Cancer: Detection of Recurrent Disease at PSA Relapse J. Nucl. Med., April 1, 2003; 44(4): 549 - 555. [Abstract] [Full Text] [PDF]

				I. J. de Jong, J. Pruim, P. H. Elsinga, W. Vaalburg, and H. J. Mensink Preoperative Staging of Pelvic Lymph Nodes in Prostate Cancer by 11C-Choline PET J. Nucl. Med., March 1, 2003; 44(3): 331 - 335. [Abstract] [Full Text] [PDF]

				R. M. Pieterman, T. H. Que, P. H. Elsinga, J. Pruim, J. W.G. van Putten, A. T.M. Willemsen, W. Vaalburg, and H. J.M. Groen Comparison of 11C-Choline and 18F-FDG PET in Primary Diagnosis and Staging of Patients with Thoracic Cancer J. Nucl. Med., February 1, 2002; 43(2): 167 - 172. [Abstract] [Full Text] [PDF]

				T. Hara, N. Kosaka, and H. Kishi Development of 18F-Fluoroethylcholine for Cancer Imaging with PET: Synthesis, Biochemistry, and Prostate Cancer Imaging J. Nucl. Med., February 1, 2002; 43(2): 187 - 199. [Abstract] [Full Text] [PDF]

				J. Kotzerke, J. E. Gschwend, and B. Neumaier PET for Prostate Cancer Imaging: Still a Quandary or the Ultimate Solution? J. Nucl. Med., February 1, 2002; 43(2): 200 - 202. [Full Text] [PDF]

				T. R. DeGrado, R. E. Reiman, D. T. Price, S. Wang, and R. E. Coleman Pharmacokinetics and Radiation Dosimetry of 18F-Fluorocholine J. Nucl. Med., January 1, 2002; 43(1): 92 - 96. [Abstract] [Full Text] [PDF]

				T. R. DeGrado, S. W. Baldwin, S. Wang, M. D. Orr, R. P. Liao, H. S. Friedman, R. Reiman, D. T. Price, and R. E. Coleman Synthesis and Evaluation of 18F-Labeled Choline Analogs as Oncologic PET Tracers J. Nucl. Med., December 1, 2001; 42(12): 1805 - 1814. [Abstract] [Full Text] [PDF]

				T. Hara 18F-Fluorocholine: A New Oncologic PET Tracer J. Nucl. Med., December 1, 2001; 42(12): 1815 - 1817. [Full Text] [PDF]

				E. Ackerstaff, B. R. Pflug, J. B. Nelson, and Z. M. Bhujwalla Detection of Increased Choline Compounds with Proton Nuclear Magnetic Resonance Spectroscopy Subsequent to Malignant Transformation of Human Prostatic Epithelial Cells Cancer Res., May 1, 2001; 61(9): 3599 - 3603. [Abstract] [Full Text]

				S. S. Gambhir, J. Czernin, J. Schwimmer, D. H. S. Silverman, R. E. Coleman, and M. E. Phelps A Tabulated Summary of the FDG PET Literature J. Nucl. Med., May 1, 2001; 42(90050): 1S - 93. [Full Text] [PDF]

				J. R. Thornbury, D. K. Ornstein, P. L. Choyke, C. P. Langlotz, and J. C. Weinreb Prostate Cancer: What Is the Future Role for Imaging? Am. J. Roentgenol., January 1, 2001; 176(1): 17 - 22. [Full Text]

				T. R. DeGrado, R. E. Coleman, S. Wang, S. W. Baldwin, M. D. Orr, C. N. Robertson, T. J. Polascik, and D. T. Price Synthesis and Evaluation of 18F-labeled Choline as an Oncologic Tracer for Positron Emission Tomography: Initial Findings in Prostate Cancer Cancer Res., January 1, 2000; 61(1): 110 - 117. [Abstract] [Full Text]

				J. D. Luketich, D. M. Friedman, T. L. Weigel, M. A. Meehan, R. J. Keenan, D. W. Townsend, and C. C. Meltzer Evaluation of distant metastases in esophageal cancer: 100 consecutive positron emission tomography scans Ann. Thorac. Surg., October 1, 1999; 68(4): 1133 - 1136. [Abstract] [Full Text] [PDF]