JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

The Journal of Nuclear Medicine Vol. 39 No. 6 974-977
© 1998 by Society of Nuclear Medicine
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sasaki, M.
Right arrow Articles by Masuda, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sasaki, M.
Right arrow Articles by Masuda, K.

Carbon-11-Methionine PET in Focal Cortical Dysplasia: A Comparison with Fluorine-18-FDG PET and Technetium-99m-ECD SPECT

Masayuki Sasaki, Yasuo Kuwabara, Tsuyoshi Yoshida, Toshimitsu Fukumura, Takato Morioka, Shunji Nishio, Masashi Fukui and Kouji Masuda

Departrments of Radiology and Neurosurgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Correspondence: For correspondence or reprints contact: Masayuki Sasaki, MD, PhD, Department of Radiology, Faculty of Medecine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

ABSTRACT

Focal cortical dysplasia is one of the known neuronal migration disorders and has recently been recognized as a cause of intractable epilepsy. In this study, we assessed the, 11C-methionine (MET) uptake in focal cortical dysplasia by PET, and then compared the results with that of 18F-fluoro-2-deoxy-D-glucose(FDG)PET and 99mTc-ethyl cysteinate dimer (ECD) SPECT. Methods: Four patients (3 men, 1 woman; age range 16–68 yr) were examined by PET and SPECT for a presurgical examination of medically intractable seizures. In all 4 patients, 11C-MET PET was performed for 15 min, started 15 min after the administration of 511–662 MBq MET. In 3 of 4 patients, FDG PET was performed for 15 min, and started 20 min after the administration of 185–370MBq FDG. In all 4 patients, the cerebral blood flow was also evaluated by 99mTc-ECD SPECT for 15 min after the administration of 600 MBq ECD. Results: In MET PET, all 4 lesions were visually recognized to have high MET uptake areas. The MET uptake of the lesions was 1.44 ± 0.30 for the standardized uptake value (SUV) (ranging from 0.99–i .61). In FDG PET, 2 lesionswere demonstrated to have low uptake areas (3.82 in SUV) while 1 had an ictal high uptake (4.74 in SUV). In ECD SPECT, 1 lesion demonstrated hypoperfusion and 1 ictal hyperperfusion while 2 showed no abnormalities. All 4 patients underwent a cortical resection and the microscopic examinations were consistent with those of focal cortical dysplasia but no evidence of a tumor was found. Conclusion: MET PET is useful for identifying focal cortical dysplasia as a high uptake area.

Key Words: epilepsy • focal cortical dysplasia • carbon-11-methionine • fluorine-18-fluorodeoxyglucose • PET




This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
P. V. Madakasira, R. Simkins, T. Narayanan, K. Dunigan, R. J. Poelstra, and J. Mantil
Cortical Dysplasia Localized by [11C]Methionine Positron Emission Tomography: Case Report
AJNR Am. J. Neuroradiol., May 1, 2002; 23(5): 844 - 846.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. B. Crino, A.-C. Duhaime, G. Baltuch, and R. White
Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia
Neurology, April 10, 2001; 56(7): 906 - 913.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 1998 by the Society of Nuclear Medicine.