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Use of Singular Value Decomposition to Characterize Age and Gender Differences in SPECT Cerebral Perfusion

Departments of Psychiatry and Neurology, Massachusetts General Hospital, Boston
Departments of Radiology and Neurology, Brigham and Women's Hospital, Boston
Clinical Research Center, Massachusetts Institute of Technology, Cambridge
Florence Heller School for Advanced Studies in Social Welfare, Brandeis University, Waltham, Massachusetts

Correspondence: For correspondence or reprints contact: Marilyn Albert, MD, Massachusetts General Hospital, Psychiatry/Gerontology (149-9124), Bldg. 149 13th SWeet, Charlestown, MA 02129.

ABSTRACT

The main objective of this study was to characterize changes in brain perfusion associated with normal aging and gender. Methods: Perfusion SPECT images using ^99mTc-hexamethy1 propyleneamine oxime (HMPAO) were obtained from 152 healthy subjects (67 men, 85 women) aged 50–92 yr. An automated method was developed to objectively assessimage data from a large number of brain regions. Image data were reduced with singular value decomposition (SVD), which produced 20 elgenvectors captunng 97.05% of the total information content of 4320 regions from each subject. Subjects were scored individually on each vector. Results: Multivariate analyses demonstrated that there were no significant differences in whole-brain HMPAO uptake with age, but age-related regional declines were seen in lateral ventricular regions. Women had higher HMPAO uptake than men in eslimates of global perfusion and regional perfusion in the midcingulate/corpus callosum, inferior temporal and inferior parietal areas. Conclusion: These discriminations demonstrate that singular value deomposition of SPECT data maybe used to assess differences in perfusion patterns between groups of subjects. They replicate several previous findings, both with respect to age-related changes in perfusion and with respect to gender differences. In addition, they identify a previously unreported gender difference in biparietal regions.

Key Words: SPECT • technelium-99m-hexamethyl propyleneamine oxime • aging • gender differences

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