HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Suga, K. Articles by Alderson, P.O. Search for Related Content PubMed PubMed Citation Articles by Suga, K. Articles by Alderson, P.O.

Effect of Inhaled Surfactant on Pulmonary Deposition and Clearance of Technetium-99m-DTPA Radioaerosol

Department of Radiology, Columbia-Presbyterian Medical Center, New York, New York

Correspondence: For correspondence contact: Kazuyoshi Suga, Department of Radiology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, Yamaguchi, 755 Japan.

Correspondence: For reprint request contact: Philip O. Alderson, Department of Radiology, Milstein 2–131, Columbia-Presbyterian Medical Center, 622 West 168th St., New York, NY 10032.

ABSTRACT

To establish the effect of an aerosolized synthetic surfactant (Exosurf) on pulmonary ^99mTc-diethylenetriamine pentaacetic acid (DTPA) aerosol deposition and clearance, radioaerosol studies were performed at varying times and under varying conditions after surfactant inhalation in canine lungs. Methods: Twenty-three dogs had a baseline ^99mTc-DTPA study; 2 days later the study was repeated after inhalation of a 1.5-ml/kg dose of Exosurf aerosolized by an ultrasonic nebulizer .The clearance half-time (T_1/2)of ^99mTc-DTPA from each lung was measured at different times (from 10 min to 3 hr) after Exosurf inhalation. For comparison, five animals had a ^99mTc-DTPA study 10 min after inhalation of the same dose of saline as Exosurf. An additional five animals inhaled a ^99mTc-DTPA-Exosurf mixture to investigate the distribution of Exosurf. Results: Received Jan. 16, 1997; revision accepted Jun. 12, 1997. Technetium-99m-DTPA distributed uniformly without significant changes in penetration indexes before and after inhalation of Exosurf and the ^99mTc-DTPA-Exosurf mixture. After Exosurf inhalation, ^99mTc-DTPA clearance at 10 min (T_1/2; 35.6 ± 8.7 min; n = 6) and 40 min (29.4 ± 6.3 min; n = 4) was significantly prolonged compared with the matched baseline values (24.7 ± 6.4 min, p < 0.0001; and 21.7 ± 8.9 min, p = 0.01, respectively). However, later clearance times were not prolonged. By contrast, after saline inhalation, ^99mTc-DTPA distributed inhomogeneously, and clearance times (T_1/2) were not altered from the matched baseline values. Conclusion: Aerosolized Exosurf distributes homogeneously in the lungs. Exosurf initially retards ^99mTc-DTPA aerosol clearance, but ^99mTc-DTPA transalveolar clearance returns to baseline rates within 1–2 hr. Technetium-99m-DTPA aerosol clearance measurements can be used to monitor the effect of inhaled Exosurf on pulmonary epithelial integrity.

Key Words: technetium-99-diethylenetriamine pentaacetic acid • surfactant • pulmonary aerosol scintigraphy • alveolar permeability

This article has been cited by other articles:

				K. Suga, Y. Yuan, N. Ogasawara, T. Tsukuda, and N. Matsunaga Altered Clearance of Gadolinium Diethylenetriaminepentaacetic Acid Aerosol from Bleomycin-injured Dog Lungs: Initial Observations Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1704 - 1710. [Abstract] [Full Text] [PDF]

				K. Suga, P. O. Alderson, A. Mitra, C. Domingues, J. Rescigno, L. G. Smith, N. Ogasawara, N. Matsunaga, and K. Sasai Early Retardation of 99mTc-DTPA Radioaerosol Transalveolar Clearance in Irradiated Canine Lung J. Nucl. Med., February 1, 2001; 42(2): 292 - 299. [Abstract] [Full Text]