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Pleomorphic Adenoma of the Salivary Glands: Correlation Between Gallium-67 Uptake and Histopathological Components

Departments of Radiology, Pathology and Otolanyngology, Saga Medical School, Saga, Japan

Correspondence: For correspondence or reprints contact: Tomonori Yoshikai, MD, Department of Radiology, Saga Medical School, Nabeshima 5-1-1, Saga 849-8501, Japan.

ABSTRACT

We correlated ⁶⁷Ga uptake and histopathological findings in pleomorphic adenomas of the salivary glands. Methods: Sixty-two pleomorphic adenomas of the salivary glands were visually graded by degree of ⁶⁷Ga uptake as negative, weakly positive or strongly positive in comparison to uptake in the nasal cavity. These adenomas were reexamined pathologically and classified as epithelial, intermediate or mesenchymal type according to their dominant histological components. The pathological presence of marginal invasion or associated sialoadenitis was also re-examined. Results: Eighteen adenomas were classified as strongly positive, eight as weakly positive and 36 as negative. Nine (50%) of the 18 strongly positive adenomas were of the epithelial type and the other nine (50%) strongly positive adenomas were of the intermediate type. While none of the strongly positive adenomas were of the mesenchymal type, 27 (75%) of the 36 negative adenomas were of the mesenchymal type. Six (75%) of the eight weakly positive adenomas were of the intermediate type. About half of the adenomas showed marginal invasion regardless of the grade of ⁶⁷Ga uptake. None of the strongly positive adenomas were associated with sialoadenitis. Conclusion: The epithelial component of pleomorphic adenomas may be responsible for ⁶⁷Ga uptake. The presence of marginal invasion or associated sialoadenitis has little relation to ⁶⁷Ga uptake in pleomorphic adenomas.

Key Words: gallium-67 • pleomorphic adenoma • salivary gland