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Scintigraphic Localization of Lymphatic Leakage Site After Oral Administration of Iodine-123-IPPA

Clinics of Nuclear Medicine and Surgery, University Hospital Charité, Humboldt University, Berlin, Germany

Correspondence: For correspondence or reprints contact: Beatrice Ines Kettner, MD, Clinic of Nuclear Medicine, University Hospital Charité, Humboldt University, Berlin, Schumannstr. 20/21, 10098 Berlin, Germany.

ABSTRACT

Chylothorax can occur secondary to traumatic lesions of the thoracic duct caused by chest injuries, surgical procedures involving the pleural space, neoplasms or malformations of the lymphatics. Methods: Lymphatic leakage sites were localized by scintigraphy after oral administration of the ¹²³I-labeled long-chain fatty acid derivative iodophenyl pentadecanoic acid (IPPA). We report on three patients with different lymphatic leakage sites and on one normal control subject. Results: IPPA scintigraphy localized the lymphatic leakage site correctly in all three patients. In two of them, the method even guided the successful surgical treatment of the leakage. Conclusion: This approach is suitable for detecting lymphatic leakages of intestinal origin.

Key Words: thoracic duct • lymphatic leakage • iodine-123-iodophenyl pentadecanoic acid

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