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Technetium-99m(V)-DMSA and Gallium-67 in the Assessment of Bone and Joint Infection

Departments of Nuclear Medicine and Orthopedics, Institute of Medicine, Kaohsiung Medical College Hospital, Kaohsiung; Department of Nuclear Medicine, National Cheng-Kung University Hospital, Kaohsiung, Taiwan

Correspondence: For correspondence or reprints contact: Bi-Fang Lee, MD, Department of Nuclear Medicine, Kaohsiung Medical College Hospital, 100 Shih-Chuan 1st Rd., Kaohsiung, Taiwan.

ABSTRACT

The aim of our study was to investigate the diagnostic value of scans with ^99mTc(V)-dimercaptosuccinic acid (DMSA) to localize bone and joint infection compared with scans using ⁶⁷Ga. Methods: Thirty-six patients referred for investigation of bone and joint infection were studied. In all patients, a bone scan was obtained initially. Subsequently, comparative scans with ^99mTc(V)-DMSA and ⁶⁷Ga were performed 1 wk apart. Microbiological findings, pathologic findings and/or clinical follow-up (until symptoms disappeared) were considered to be proof of the presence of bone and joint infection. Results: Technetium-99m(V)-DMSA showed greater sensitivity and accuracy than ⁶⁷Ga in the assessment of bone and joint infection, although the difference was not statistically significant. Conclusion: In comparison with a ⁶⁷Ga scan, a ^99mTc(V)-DMSA scan, in combination with a bone scan, is a reliable way to diagnose bone and joint infection. Both tracers were useful in the diagnosis of bone and joint infection.

Key Words: technetium-99m(V)-dimercaptosuccinic acid • gallium-67 • bone and joint infection

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