| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Divisions of Neuroimaging Research and Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
Correspondence: For correspondence or reprints contact: Kazunari Ishii, MD, Division of Neuroimaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-Ko, Himeji City, Hyogo 670-0981, Japan.
ABSTRACT
Frontotemporal dementia (FID) is a dementia syndrome characterized by peculiar behavioral changes arising from frontotemporal involvement and distinct from Alzheimer's disease (AD). The purpose of this study was to elucidate the specific patterns in cerebral glucose metabolism in patients with FTD and to compare them with the patterns in patients with AD and normal elderly subjects using fluorodeoxyglucose (FDG) and PET. Methods: Twenty-one patients with a clinical diagnosis of FTD [mean age 67.0 ± 7.0 yr, Mini Mental State Examination (MMSE) score 18.7 ± 5.7], 21 age-, sex- and dementia-severity-matched patients with probable AD (mean age 66.9 ± 7.1 yr, MMSE score 20.2 ± 5.5) and 21 age-and sex-matched normal control subjects (mean age 66.8 ± 5.7 yr) were studied. The cerebral metabolic rate for glucose (CMRglc) was measured with FDG and PET. Absolute measures of regional CMRglc were compared among the three groups. One-way ANOVA and the posthoc Tukey HSD test were used for statistical analyses. Results: In the FTD group, CMRglc was preserved only in the left cerebellum, right sensorimotor area and occipital lobes. The CMRglc was significantly lower in the FTD group as opposed to the AD group in the hippocampi, orbital gyri, anterior temporal lobes, anterior cingulate gyri, basal ganglia, inalami, middle and superior frontal gyri and left inferior frontal gyrus. Conclusion: Although metabolic abnormality in FTD is predominant in the frontal and anterior temporal lobes and the subcortical structures, it is more widespread than has been previously stressed. These findings document an FTD-specific cerebral involvement and facilitate differ ential diagnosis of degenerative dementias.
Key Words: frontotemporal dementia • Alzheimer's disease • cerebral metabolic rate for glucose • fluorodeoxyglucose • PET
This article has been cited by other articles:
|
|
 |
|
  L. Mosconi, W. H. Tsui, K. Herholz, A. Pupi, A. Drzezga, G. Lucignani, E. M. Reiman, V. Holthoff, E. Kalbe, S. Sorbi, et al. Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias J. Nucl. Med., March 1, 2008; 49(3): 390 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. W. Seeley, R. Crawford, K. Rascovsky, J. H. Kramer, M. Weiner, B. L. Miller, and M. L. Gorno-Tempini Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia Arch Neurol, February 1, 2008; 65(2): 249 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K HERHOLZ, S F CARTER, and M JONES Positron emission tomography imaging in dementia Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S160 - S167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Foster, J. L. Heidebrink, C. M. Clark, W. J. Jagust, S. E. Arnold, N. R. Barbas, C. S. DeCarli, R. Scott Turner, R. A. Koeppe, R. Higdon, et al. FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease Brain, October 1, 2007; 130(10): 2616 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Jagust, B. Reed, D. Mungas, W. Ellis, and C. DeCarli What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia? Neurology, August 28, 2007; 69(9): 871 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A D MURRAY Imaging in dementia Imaging, June 1, 2007; 19(2): 133 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Rabinovici, A. J. Furst, J. P. O'Neil, C. A. Racine, E. C. Mormino, S. L. Baker, S. Chetty, P. Patel, T. A. Pagliaro, W. E. Klunk, et al. 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration Neurology, April 10, 2007; 68(15): 1205 - 1212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. L. Ber, E. Guedj, A. Gabelle, P. Verpillat, M. Volteau, C. Thomas-Anterion, M. Decousus, D. Hannequin, P. Vera, L. Lacomblez, et al. Demographic, neurological and behavioural characteristics and brain perfusion SPECT in frontal variant of frontotemporal dementia. Brain, November 1, 2006; 129(Pt 11): 3051 - 3065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Du, G. H. Jahng, S. Hayasaka, J. H. Kramer, H. J. Rosen, M. L. Gorno-Tempini, K. P. Rankin, B. L. Miller, M. W. Weiner, and N. Schuff Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI. Neurology, October 10, 2006; 67(7): 1215 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jeong, K. C. Park, S. S. Cho, E. J. Kim, S. J. Kang, S. E. Kim, E. Kang, and D. L. Na Pattern of glucose hypometabolism in frontotemporal dementia with motor neuron disease Neurology, February 22, 2005; 64(4): 734 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jeong, S. S. Cho, J. M. Park, S. J. Kang, J. S. Lee, E. Kang, D. L. Na, and S. E. Kim 18F-FDG PET Findings in Frontotemporal Dementia: An SPM Analysis of 29 Patients J. Nucl. Med., February 1, 2005; 46(2): 233 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H.S. Silverman Brain 18F-FDG PET in the Diagnosis of Neurodegenerative Dementias: Comparison with Perfusion SPECT and with Clinical Evaluations Lacking Nuclear Imaging J. Nucl. Med., April 1, 2004; 45(4): 594 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A.R.B. Rombouts, J. C. van Swieten, Y. A.L. Pijnenburg, R. Goekoop, F. Barkhof, and P. Scheltens Loss of frontal fMRI activation in early frontotemporal dementia compared to early AD Neurology, June 24, 2003; 60(12): 1904 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Kizu, K. Yamada, and T. Nishimura Proton Chemical Shift Imaging in Pick Complex AJNR Am. J. Neuroradiol., September 1, 2002; 23(8): 1387 - 1392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H.S. Silverman and G. W. Small Prompt Identification of Alzheimer's Disease With Brain PET Imaging of a Woman With Multiple Previous Diagnoses of Other Neuropsychiatric Conditions Am J Psychiatry, September 1, 2002; 159(9): 1482 - 1488. [Full Text] [PDF]
|
|
|
|
|
|
J. O. Rinne, M. Laine, V. Kaasinen, M.K. Norvasuo-Heila, K. Nagren, and H. Helenius Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia Neurology, May 28, 2002; 58(10): 1489 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Knopman, S. T. DeKosky, J. L. Cummings, H. Chui, J. Corey-Bloom, N. Relkin, G. W. Small, B. Miller, and J. C. Stevens Practice parameter: Diagnosis of dementia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology Neurology, May 8, 2001; 56(9): 1143 - 1153. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
