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Evaluation of Glomerular Filtration Rate by Camera-Based Method in Both Children and Adults

Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo; Departments ofRadiology and Urology, University of Tokyo, Tokyo, Japan

Correspondence: For correspondence or reprints contact: Yusuke inoue, MD, Department of RadiOlogy, Institute of Medical Salence, Universfty of Tokyo, 4-6-1 Shirokanedal, Minato-ku, Tokyo 108, Japan.

ABSTRACT

We describe a method to evaluate glomerular filtration rate (GFR) in both children and adults using ^99mTc-diethylenefriamine pentaacetic acid (DTPA) and a gamma camera. Methods:Renal scintigraphy with ^99mTc-DTPA was performed in 40 children and 92 adults with various degrees of renal function. The percent renal uptake at 2–2.5 min after tracer arrival in the kidney was determined with back ground subtraction and correction for soft-tissue attenuation and was correlated by linear regression analysis with GFR measured from two blood samples. A perirenai region of interest was used for background subtraction. Renal depth was computed using the equations determined or validated on the basis of CT measurements, and the attenuation coefficient was set at 0.12. The obtained regression equation was used to predict GFR. Renal function was also assessed by the Gates' method. Results: Percent renal uptake was closely correlated with GFR normalized for body surface area in all patients (y =15.958x – 2.94;r = 0.939). GFR was successfully predicted using the regression equation in both children and adults. Gates' method severely overestimated GFR in children and provided less accurate values even in adults than our method. Conclusion:The method presented here requires neither blood sampling nor additional imaging and allows estimation of GFR in both children and adults.

Key Words: glomerular filtration rate • technetium-99m-diethylenetriamine pentaacetic acid • children • adults • gamma camera