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PET Methodology and Cardiology Groups, Cyclotron Unit, MRC Clinical Sciences Centre, Hammersmith Hospital, London; Department of Cardiology, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
Correspondence: For correspondence or reprints contact: Flemming Hermansen, MD, PET Center, Aarhus General Hospital, 44 Norrebrogade, Aarhus C. Denmark DK-8000.
ABSTRACT
The measurement of regional myocardial blood flow (MBF) with H215O and PET requires an additional C15O blood-pool scan for the purpose of region of interest (ROI) definition. This additional scan results in a substantially increased radiation dose, study duration and risk of movement artifacts. Therefore, a method was developed to generate myocardial factor images directly from the dynamic H215O studyWithOuttheneedfora C15O scan. Methods: The factor sinograms were generated by means of linear dimension reduction of the dynamic sinograms,where the required variate and covariate factors (myocardial and blood time-activity curves) were modeled from the lung time-activity curve. The factor images were generated by iterative reconstruction. Results: No signfficant difference was found between MBF values from ROls drawn on the traditional images(usmng the C15O scan) and those drawn on the factor images. Conclusion: It is possible to generate myocardial images directly from the dynamo H215O study, so that the C15O scan can be omitted from MBF studies. The proposed method is robust and results in nearly optimal signal-to-noise ratios in the factor images.
Key Words: PET • myocardial blood flow • factor analysis • myocardial and biood-pool images
FOOTNOTES
Present address: Adriaan A. Lammertsma, PhD, PET Centre, Free University Hospital, Amsterdam, The Netherlands.
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