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Iterative Reconstruction of Fluorine-18 SPECT Using Geometric Point Response Correction

University of Utah, Salt Lake City, Utah
Picker International, Inc., Cleveland, Ohio

Correspondence: For correspondence or reprints contact: Grant T. Gullberg, PhD, Department of Radiology, 729 Arapeen Dr., University of Utah, Salt Lake City, UT 84108-1218.

ABSTRACT

This article demonstrates resolution recovery in ¹⁸F SPECT imagereconstruction by using an iterative algorithm that corrects for thesystem geometric response. Methods: Patient and phantom studieswere performed using a Picker PRISM 3000 three-detectorSPECT system (Picker International, Inc., Cleveland, OH) to image¹⁸F with 511 keV collimators. A measured point response function ofthe imaging system was used in an iterative reconstruction algorithmin which the projector and backprojector modeled the systempoint response function by using an efficient layer-by-layer blurringtechnique. The blurring function was a five-element kernel in theshape of a cross. The iterative reconstruction algorithm was anordered-subset maximum-likelihood expectation maximization algorithm.Results: The iterative reconstruction algorithm with geometricresponse correction showed an improvement in resolutionover the filtered backprojection reconstruction and the iterativereconstruction without correction. Conclusion: The proposed iterativereconstruction algorithm with geometric response correction isefficient and effective with significant resolution recovery.

Key Words: fluorine-18-fluorodeoxyglucose • SPECT • geometric point response correction

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