HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dams, E. T.M. Articles by Corstens, F. H.M. Search for Related Content PubMed PubMed Citation Articles by Dams, E. T.M. Articles by Corstens, F. H.M.

Technetium-99m Labeled to Human Immunoglobulin G Through the Nicotinyl Hydrazine Derivative: A Clinical Study

Departments of Nuclear Medicine and Internal Medicine, University Hospital Nijmegen, and Department of Orthopedics, St. Maartenskliniek, Nijmegen, The Netherlands

Correspondence: For correspondence or reprints contact: E.Th., M. Dams, MD, Department of Internal Medicine, University Hospital, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

ABSTRACT

A novel method to label polyclonal human immunoglobulin G (IgG) with ^99mTc through the nicotinyl hydrazine derivative (HYNIC) has shown promising results in the detection of experimental infection. In this study, ^99mTc-labeled HYNIC-IgG was directly compared to ¹¹¹In-labeled diethylenetriaminepentaacetic acid (DTPA)-IgG in patients suspected of infectious or inflammatory disease. Methods: Thirty-seven patients (22 women and 15 men; mean age = 54 yr, range = 17–78 yr) with 39 suspected infectious or inflammatory foci were prospectively studied. After administration of 740 MBq ^99mTc-HYNIC-IgG, imaging was performed at 4 and 24 hr postinjection. To avoid cross-over activity, ¹¹¹In-DTPA-IgG was injected 24 hr after ^99mTc-HYNIC-IgG and imaged at 4, 24 and 48 hr postinjection. The scintigraphic results were confirmed by microbiological, histological, radiological and clinical methods. Results: Technetium-99m-HYNIC-IgG and ¹¹¹In-DTPA-IgG scintigraphy showed 100% concordancy. All 17 patients with proven infection or inflammation (19 foci, mainly localized in the locomotor system) had positive scintigraphic findings. No false-negative scintigrams were recorded. In three patients, the scintigrams were concordantly false-positive. As a result, the sensitivity and specificity of imaging infectious or inflammatory foci with ^99mTc-HYNIC-IgG and ¹¹¹In-DTPA-IgG in these patients were 100% and 85%, respectively. Conclusion: Technetium-99m-HYNIC-IgG scintigraphy is equally as effective as ¹¹¹In-IgG scintigraphy for the detection of infection and inflammation. The apparent physical and logistic advantages of ^99mTc over ¹¹¹In make ^99mTc-HYNIC-IgG a promising new radiopharmaceutical for imaging infection and inflammation.

Key Words: infection • inflammation • immunoglobulin G • HYNIC • imaging

This article has been cited by other articles:

				P Barrera, W J G Oyen, O C Boerman, and P L C M van Riel Scintigraphic detection of tumour necrosis factor in patients with rheumatoid arthritis Ann Rheum Dis, September 1, 2003; 62(9): 825 - 828. [Abstract] [Full Text] [PDF]

				A. Goel, J. Baranowska-Kortylewicz, S. H. Hinrichs, J. Wisecarver, G. Pavlinkova, S. Augustine, D. Colcher, B. J.M. Booth, and S. K. Batra 99mTc-Labeled Divalent and Tetravalent CC49 Single-Chain Fv's: Novel Imaging Agents for Rapid In Vivo Localization of Human Colon Carcinoma J. Nucl. Med., October 1, 2001; 42(10): 1519 - 1527. [Abstract] [Full Text] [PDF]