HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Senden, T. J. Articles by Heath, G. A. Search for Related Content PubMed PubMed Citation Articles by Senden, T. J. Articles by Heath, G. A.

The Physical and Chemical Nature of Technegas

Department of Physics, University College ,University of New South Wales, canberra Research School of Chemistry, Research School of Earth Sciences, and John Curtin School of Medical Research, and Australian National University, Canberra, Australia

Correspondence: For correspondence or reprints contact: Tim Senden, PhD, Dept. of Applied Mathematics, Research School of Physical and Engineering, Australian National University, Canberra, ACT, 0200, Australia.

ABSTRACT

Technegas, the discrete radio-aerosol particle, containing ^99mTc has been investigated, and the chemical evolution and physical properties of the particle demonstrated. Methods: A commercial techne-gas generator was used to produce aerosols according to standard clinical procedures. The aerosols were collected by electrostatic precipitation and examined with transition electron microscopy (TEM), scanning electron microscopy (SEM) and force microscopy. The chemical evolution was examined by x-ray techniques and thermogravimetric analysis. Results: The active particle was identified as hexagonal platelets of metallic technetium contained within a thin layer of graphitic carbon. This composite structure is discussed in light of the metal particle behaving as a template for the carbon capsule. The average size of the observed hexagonal platelets, 30-60 nm, was only weakly dependent on the concentration of technetium in the crucible. Conclusion: The mechanism for the formation of the technegas particles has been developed and the particles involved characterized. It appears that the use of other metals also leads to the formation of similiar materials.

Key Words: technegas • lung • aerosol • technetium-99m-pertechne-tate

This article has been cited by other articles:

				J. Petersson, A. Sanchez-Crespo, S. A. Larsson, and M. Mure Physiological imaging of the lung: single-photon-emission computed tomography (SPECT) J Appl Physiol, January 1, 2007; 102(1): 468 - 476. [Abstract] [Full Text] [PDF]

				P. Wiebert, A. Sanchez-Crespo, J. Seitz, R. Falk, K. Philipson, W. G. Kreyling, W. Moller, K. Sommerer, S. Larsson, and M. Svartengren Negligible clearance of ultrafine particles retained in healthy and affected human lungs Eur. Respir. J., August 1, 2006; 28(2): 286 - 290. [Abstract] [Full Text] [PDF]

				P. Reinartz, H.-J. Kaiser, J. E. Wildberger, C. Gordji, B. Nowak, and U. Buell SPECT Imaging in the Diagnosis of Pulmonary Embolism: Automated Detection of Match and Mismatch Defects by Means of Image-Processing Techniques J. Nucl. Med., June 1, 2006; 47(6): 968 - 973. [Abstract] [Full Text] [PDF]

				P. Reinartz, J. E. Wildberger, W. Schaefer, B. Nowak, A. H. Mahnken, and U. Buell Tomographic Imaging in the Diagnosis of Pulmonary Embolism: A Comparison Between V/Q Lung Scintigraphy in SPECT Technique and Multislice Spiral CT J. Nucl. Med., September 1, 2004; 45(9): 1501 - 1508. [Abstract] [Full Text] [PDF]

				J. Petersson, A. Sanchez-Crespo, M. Rohdin, S. Montmerle, S. Nyren, H. Jacobsson, S. A. Larsson, S. G. E. Lindahl, D. Linnarsson, R. W. Glenny, et al. Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion J Appl Physiol, March 1, 2004; 96(3): 1127 - 1136. [Abstract] [Full Text] [PDF]

				A. Nemmar, P.H.M. Hoet, B. Vanquickenborne, D. Dinsdale, M. Thomeer, M.F. Hoylaerts, H. Vanbilloen, L. Mortelmans, and B. Nemery Passage of Inhaled Particles Into the Blood Circulation in Humans Circulation, January 29, 2002; 105(4): 411 - 414. [Abstract] [Full Text] [PDF]

				H.U. Kauczor, X.J. Chen, E.J.R. van Beek, and W.G. Schreiber Pulmonary ventilation imaged by magnetic resonance: at the doorstep of clinical application Eur. Respir. J., May 1, 2001; 17(5): 1008 - 1023. [Abstract] [Full Text] [PDF]

				I. J.C. Hartmann, P. J. Hagen, M. P.M. Stokkel, O. S. Hoekstra, and M. H. Prins Technegas Versus 81mKr Ventilation-Perfusion Scintigraphy: A Comparative Study in Patients with Suspected Acute Pulmonary Embolism J. Nucl. Med., March 1, 2001; 42(3): 393 - 400. [Abstract] [Full Text]