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Intra-Individual Differences Between Technetium-99m-HMPAO and Technetium-99m-ECD in the Normal Medial Temporal Lobe

Division of Nuclear Medicine, First Department of Medicine and Departments of Neurology and Tracer Kinetics, Osaka University Medical School, Osaka, Japan

Correspondence: For correspondence or reprints contact: Naohiko Oku, MD, First Department of Medicine, Osaka University Medical School, Yamada-oka 2-2, Suita 565, Osaka, Japan.

ABSTRACT

Regional distributions of ^99mTc-hexamethyl propyleneamine oxime (^99mTc-HMPAO) and ^99mTc-ethyl cysteinate dimer (^99mTc-ECD) were compared in the normal brain. Methods: Six paid, healthy volunteers (mean age 26 yr) had high-resolution neuroperfusion SPECT using both ^99mTc-HMPAO and ^99mTc-ECD on separate days. Results: Regional distribution of the two tracers differed. Technetium-99m-HMPAO accumulated more in the thalamus, frontal lobe, temporal lobe and cerebellum than ^99mTc-ECD, which accumulated more in the occipital and parietal lobes. There was a considerable difference in the accumulations of the two tracers in the medial temporal lobe. The percent accumulations of ^99mTc-HMPAO and ^99mTc-ECD in the medial temporal lobe compared with the mean global cerebral cortical accumulation were 93.9% ± 2.4% and 83.1% ± 4.1% (mean ± s.d.), respectively. Conclusion: The results suggest that ^99mTc-HMPAO and ^99mTc-ECD require specific and separate criteria for diagnosing temporal lobe pathologies, such as dementia and temporal lobe epilepsy.

Key Words: technetium-99m-HMPAO • technetium-99m-ECD • SPECT • hippocampus

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