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Quantification of Left Ventricular Function with Thallium-201 and Technetium-99m-Sestamibi Myocardial Gated SPECT

Division of Nuclear Medicine, Department of Radiology, University of Maryland Medical System, Baltimore, Maryland

Correspondence: For correspondence or reprints contact: Christophe Maunoury, MD, Service de Médecine Nucléaire Cardiologique, Hôpital Necker, 149 rue de Sèvres,75743 Paris Cedex 15, France.

ABSTRACT

Myocardial gated SPECT with ^99mTc-sestamibi has been used to quantify left ventricular function. The purpose of this study was to determine if myocardial gated SPECT with ²⁰¹TI was possible and reliable to quantify left ventricular function. Methods: One hundred and four patients referred for a myocardial perfusion study were included. Myocardial gated SPECT acquisition was performed 15 min after the intravenous injection of 111 MBq (3 mCi) ²⁰¹TI and at 1 hr postinjection of 925 MBq (25 mCi) ^99mTc-sestamibi. A commercially available automated myocardial gated SPECT processing software was used. Parameters evaluated were left ventricular ejection fractions (LVEF), end-diastolic volumes (EDV), end-systolic volumes (ESV) and stroke volumes (SV). Results: The correlation be tween gated SPECT with ²⁰¹TI and gated SPECT with ^99mTc-sestamibi was: r = 0.93 for LVEF, 0.92 for EDV, 0.96 for ESV and 0.68 for SV. Conclusion: Myocardial gated SPECT quantification of left ventricular function with 201T1was possible and as reliable as gated SPECT with ^99mTc-sestamibi. There was excellent correlation between gated SPECT with 201T1and gated SPECT with ^99mTc-sestamibi. In addition to assessment of myocardial perfusion, myocardial function and viability can be quantified in a single gated ²⁰¹TI study.

Key Words: myocardialgated SPECT • left ventricular function • thallium-201 • technetium-99m-sestamibi

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