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Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland; Departments of Radiology and Nuclear Medicine, Cardiology and Clinical Epidemiology and Biostatistics, Hospital of the University of Pennsylvania, Philadephia, Pennsylvania
Correspondence: For correspondence or reprints contact: Bennett Chin, MD, Assistant Professor of Radiology, Johns Hopkins Medical Institutes, Nelson Bldg., B1–119, Baltimore, MD 21287.
ABSTRACT
Tomographic techniques separate overlying structures, permitting measurements of absolute ventricular volumes. The purpose of this study was to determine absolute right and left ventricular volume and ejection fraction measurements with tomographic gated equilibrium blood-pool scintigraphy (TMUGA) compared to MRI and conventional planar scintigraphy. Methods: Eighteen patients were studied. Ventricular volumes for TMUGA and MRI were calculated by modified Simpson's rule. TMUGA regions were defined by constraints including phase analysis, intensity threshold and visual inspection. MRI studies were acquired with a fast gradient-echo, ECG-gated, breath-hold technique and boundaries were defined by a semiautomated contour method. Conventional gated first-pass radionuclide angiography (FP) and planar gated equilibrium blood-pool scintigraphy (PMUGA) were performed for RV EF and LV EF, respectively. Results: TMUGA absolute right ventricular volumes showed excellent correlation with MRI for both right ventricular volumes (r = 0.91, slope = 0.90, s.e.e. = 15.7) and left ventricular volumes (r = 0.96, slope = 0.88, s.e.e. = 18.2). For left ventricular ejection fraction, TMUGA also showed excellent correlation with MRI (r = 0.94, slope = 1.10, s.e.e. = 9.0) and planar MUGA (r = 0.97, slope = 1.23, s.e.e. = 6.2). For right ventricular ejection fraction, TMUGA showed good correlation with both MRI (r = 0.88, slope = 0.79, s.e.e. = 6.0) and first-pass planar scintigraphy (r = 0.86, slope = 1.2, s.e.e. = 7.9). Conclusion: Tomographic gated blood-pool scintigraphy absolute right and left ventricular volumes and ejection fractions show good correlation with accepted techniques. Further studies are necessary to define the reproducibility of this method.
Key Words: tomographic equilibrium gated blood-pool scintigraphy • magnetic resonance imaging • cardiac volume
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