HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Prvulovich, E. M. Articles by Ell, P. J. Search for Related Content PubMed PubMed Citation Articles by Prvulovich, E. M. Articles by Ell, P. J.

Clinical Evaluation of Technetium-99m-L,L-Ethylenedicysteine in Patients with Chronic Renal Failure

Institute of Nuclear Medicine, University College London Medical School, London, United Kingdom
Laboratory of Radiopharmaceutical Chemistry, Catholic University, Leuven, Belgium

Correspondence: For correspondence or reprints contact: Jamshed B. Bomanji, MD, Institute of Nuclear Medicine, University College London Medical School, Mortimer St., London W1N 8AA, United Kingdom.

ABSTRACT

Technetium-99m-L,L-ethylenedicysteine (^99mTc-L,L-EC), a new renal radiopharmaceutical, has been shown to have similar excretion characteristics but a higher plasma clearance than ^99mTc-mercaptoacetyltriglycine (^99mTc-MAG3) in normal volunteers and patients with obstructive nephropathy. This study evaluated ^99mTc-L,L-EC in patients with chronic renal failure. Methods: The clearance of ^99mTc-L,L-EC was compared with that of ¹²⁵I-hippuran in 26 patients with varying degrees of chronic renal impairment (serum creatinine 168-1163 µmol/liter). All 26 patients also were imaged with ^99mTc-L,L-EC(70–80 MBq). Fifteen patients had further imaging with ^99mTc-MAG3 (100 MBq) the following day. Results: A subjective analysis of the ^99mTc-L,L-EC images revealed that all were of acceptable quality regardless of creatinine level. In the 15 patients who were imaged wfth both ^99mTc-L,L-EC and ^99mTc MAG3, general image quality and target-to-background ratios were similar. Time-activity curves and mean parenchymal transit times obtained with the two agents were almosti dentical. Plasma clearance values (mean ± s.d.) of ^99mTc-L,L-EC and ¹²⁵I-hippuran were 81 ± 68 ml/min and 114 ± 104 ml/min, respectively. Mean ^99mTc L,L-EC clearance was 71% of the mean ¹²⁵I-hippuran value. Conclusion: Technetium-99m-L,L-EC provides equally high-quality images to ^99mTc-MAG3 in patients with chronic renal failure. Technetium-99m-L,L-EC clearance more closely resembles that of hippuran than does ^99mTc-MAG3 clearance. These features together with its ease of preparation make ^99mTc-L,L-EC an attractive alternative to ^99mTc-MAG3 in patients with chronic renal failure.

Key Words: chronic renal failure • technetium-99m-L,L-EC

This article has been cited by other articles:

				M. S. Madhukar, M. S. Genidy, and J. D. Russell A New Method to Reduce Cure-Induced Stresses in Thermoset Polymer Composites, Part I: Test Method Journal of Composite Materials, November 1, 2000; 34(22): 1882 - 1904. [Abstract] [PDF]