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Normal Fusion for Three-Dimensional Integrated Visualization of SPECT and Magnetic Resonance Brain Images

Image Sciences Institute and Department of Psychiatry, Utrecht University/University Hospital, Utrecht, The Netherlands

Correspondence: For correspondence or reprints contact: Rik Stokking, University Hospital Utrecht, E 01.334, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

ABSTRACT

Multimodality visualization aims at efficiently presenting integrated information obtained from different modalities, usually combining a functional modality (SPECT, PET, functional magnetic resonance imaging) with an anatomical modality [CT, magnetic resonance imaging (MRI)]. This paper presents a technique for three-dimensional integrated visualization of SPECT and magnetic resonance brain images, where MRI is used as a framework of reference for the display of the SPECT data. Methods: A novel technique for three-dimensional integrated visualization of functional and anatomical information, called normal fusion, is presented. With this technique, local functional information is projected onto an anatomic structure. Results: The normal fusion technique is applied to three cases of SPECT/MRI integration. The results are presented, discussed and evaluated for clinical relevance. Conclusion: The results for three-dimensional integrated display of SPECT and MR brain images indicate that the normal fusion technique provides a potentially comprehensive and diagnostically valuable presentation of cerebral blood perfusion in relation to the anatomy of the brain.

Key Words: multimodality display • volume visualization • magnetic resonance imaging • SPECTSPECT • brain imaging

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