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Technetium-99m MIBI to Assess Coronary Collateral Flow During Acute Myocardial Infarction in Two Closed-Chest Animal Models

Division of Cardiovascular Diseases and Internal Medicine and Departments of Nuclear Medicine and Physiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Correspondence: For correspondence or reprints contact: Timothy F. Christian, MD, Mayo Clinic, 200 First Street Southwest, East 16B, Rochester, MN 55905.

ABSTRACT

Collateral flow Is an independent determinant of infarct-size in both animal and clinical studies of myocardial infarction. The purpose of this study was to quantitatively evaluate, in a closed-chest animal model, a noninvasive method of measuring coronary collateral flow over a wide spectrum of collateral flow rates from a tracer that can be injected during occlusion but measured after reperfusion. Methods: Fourteen animals underwent 40 min of coronary occlusion using a closed-chest technique. Two closed-chest models representing different rates of collateral flow were used: canine and porcine. Coronary blood flow was measured by radiolabeled microspheres. Collateral blood within the risk zone was estimated from the severity of ^99mTc-sestamibi tomographic perfusion defect. Results: Collateral blood flow was significantly higher in the canine model than it was in the porcine model. There was close agreement (r = 0.90) between absolute collateral flow by microspheres and the severity of the tomographic perfusion defect. Conclusion: These results suggest that an accurate noninvasive estimate of collateral blood flow can be provided by an intravenous injection of ^99mTc-sestamibi.

Key Words: collateral circulation • radionuclide imaging • coronary blood flow

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