HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ohtomo, K. Articles by Fukuma, H. Search for Related Content PubMed PubMed Citation Articles by Ohtomo, K. Articles by Fukuma, H.

Thallium-201 Scintigraphy to Assess Effect of Chemotherapy in Osteosarcoma

Divisions of Nuclear Medicine and Orthopedic Surgery, National Cancer Center Hospital, Tokyo, Japan
Adviser for Bone Tumor Pathology in the Committee of Musculoskeletal Tumor, Japanese Orthopaedic Association, Tokyo, Japan

Correspondence: For correspondence contact: Shoji Terui, MD, Division of Nuclear Medicine, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104, Japan.

Correspondence: For reprints contact: Katsuyiki Ohtomo, MD, Department of Orthopedic Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.

ABSTRACT

Imaging results in patients with high-grade osteosarcoma of the extremities were reviewed to determine whether scintigraphic appearance correlated with histologic response to preoperative chemotherapy. Methods: Histologically, the percent tumor necrosis in specimens from 30 patients were classified into three grades: grade 1 = necrosis less than 60%, grade 2 = 60–89%necrosis and grade 3 = diffuse necrosis greater than 90% based upon whole transverse sections. Scintigraphically, we analyzed ²⁰¹Tl uptake before and after preoperative chemotherapy. The changes in the tumor-to-background ratio were defined by an alteration ratio. Results: Of the 11 patients with a grade 1 response, the ratio showed –67.1 % ± 45.4% (mean ± s.d.). Of the 9 patients with a grade 2 response, the ratio showed 37.9% ± 29.9% of the 10 patients with a grade 3 response the ratio showed 105.5% ± 12.4%. The ratios correlated well with the histologic grades (p < 0.0001; analysis of variance). Conclusion: Thallium-201 scintigraphy accurately assesses the effect of chemotherapy on osteosarcoma.

Key Words: thallium-201-chloride • osteosarcoma preoperative the chemotherapy

This article has been cited by other articles:

				F. C. Eilber, G. Rosen, J. Eckardt, C. Forscher, S. D. Nelson, M. Selch, F. Dorey, and F. R. Eilber Treatment-Induced Pathologic Necrosis: A Predictor of Local Recurrence and Survival in Patients Receiving Neoadjuvant Therapy for High-Grade Extremity Soft Tissue Sarcomas J. Clin. Oncol., July 1, 2001; 19(13): 3203 - 3209. [Abstract] [Full Text] [PDF]