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Bone Scintigraphy in Hungry Bone Syndrome Following Parathyroidectomy

Departments of Nuclear Medicine and Nephrology, Carmel Medical Center, Haifa, Israel

Correspondence: For correspondence or reprints contact: Ruth Hardoff, MD, DSc, Department of Nuclear Medicine, Carmel Hospital, 7 Michal St., Haifa 34362, Israel.

ABSTRACT

A 59-yr-old man with chronic renal failure was admitted for evaluation of generalized skeletal pain and frontal bone mass, which was lytic on radiography. Bone scintigraphy demonstrated several foci of moderately increased uptake, without involvement of the skull mass. Radiographs of these lesions were compatible with brown tumors. Serum parathormone level was elevated and CT demonstrated a lower right cervical mass, consistent with parathyroid tumor. Following the removal of the mass and decrease in parathormone levels, the patient suffered from a prolonged period of hypocalcemia and his bone pain worsened. Repeat bone scintigraphy showed an increase in the number and intensity of the areas of focal uptake, consistent with hungry bone syndrome. This flare-up phenomenon is due to an increase in bone metabolism and is an uncommon finding following parathyroidectomy for primary hyperparathyroidism.

Key Words: hyperparathyroidism • brown tumor • bone scintigraphy • parathyroidectomy • hungry bone syndrome