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Peptide T and Glucose Metabolism in AIDS Dementia Complex

Brain Imaging Section, Intramural Research Program, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, Maryland
Department of Radiology, Johns Hopkins University School of Medicine; Baltimore, Maryland
AIDS Clinical Research Center, Baltimore; Washington, DC
Peptide Research, Rockville, MD
Medications Development Division, NIDA, NIH, Rockville, Maryland

Correspondence: For correspondence or reprints contact: Edythe D. London, PhD, Chief, Brain Imaging Section, NIDA Intramural Research Program, PO Box 5180, Baltimore, MD 21224.

ABSTRACT

AIDS dementia complex (ADC) is the most common presenting neurologic manifestation of human immunodeficiency virus (HIV)-1 infection. We report FDG-PET studies in a 39 yr-old man who had ADC and completed a l2-wk treatment protocol with 1.2 mg/day of intranasal peptide T, one before and one after 12 wk of treatment with peptide T. Peptide T is an octapeptide under investigation for treatment of ADC patients. Values of rCMRglc were converted to Z scores using the mean and standard deviation of values of rCMRglc in three HIV-seronegative matched controls, each of which was studied twice, at the beginning and end of a l2-wk interval. Thirty five of 60 regions assayed showed Z scores with absolute values 3 (considered abnormal) in the baseline study. Regions with high absolute values of Z scores were located in subcortical areas and in the limbic system, and to a lesser degree in the frontal, temporal and parietal lobes. Thirty-four of these 35 regions showed remission (decrease in the absolute values of Z scores) after treatment. Only one region showed no improvement in the second study. Three regions with absolute values of Z scores <3 in the baseline study manifested Z scores with magnitudes 3 in the second study. These preliminary observations suggest that functional neuroimaging techniques provide a useful tool in the evaluation of the response to treatment in ADC patients.

Key Words: AIDS dementia • peptide T • glucose metabolism • brain imaging

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