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Skeletal Muscle Uptake of Fluorine-18-FDG: Effect of Oral Diazepam

Clinical PET Center, University Medical and Dental Schools of Guys and St. Thomas's Hospitals, London, United Kingdom

Correspondence: For correspondence or reprints contact: Sally F. Barrington, MBBS, Clinical PET Center, St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, United Kingdom.

ABSTRACT

We have observed a pattern of symmetrically increased uptake of [¹⁸F]fluorodeoxyglucose (FDG) in the neck and thoracic paravertebral regions of several patients referred for whole-body PET. The distribution is suggestive of uptake in contracting skeletal muscle in tense patients. Methods: To test this hypothesis, six successive patients who exhibited this pattern of uptake underwent rescanning using an identical imaging protocol but with oral diazepam before injection of FDG. Results: The increased neck and paravertebral uptake was significantly reduced or abolished with diazepam, confirming the supposition that this increased neck and paravertebral uptake represents a normal variant of muscle uptake. Conclusion: Oral diazepam given before the uptake period can be helpful in such patients to exclude the masking of potential abnormalities by this characteristic pattern of FDG uptake.

Key Words: fluorine-18-fluorodeoxyglucose • muscles • glucose metabolism • diazepam

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