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Thallium-201 Uptake, Histopathological Differentiation and Na-K ATPase in Lung Adenocarcinoma

First Department of Medicine and Department of Nuclear Medicine, School of Medicine, Hokkaido University
Third Department of Medicine, School of Medicine, Sapporo Medical University, Sapporo, Japan

Correspondence: For correspondence or reprints contact: Hironori Takekawa, MD, Department of Respiratory Medicine, Nikko Memorial Hospital, 1-5-13 Shintomi-cho, Muroran 051, Japan.

ABSTRACT

To clarify differences in accumulation in ²⁰¹Tl scintigraphy, we examined the relationship between uptake of ²⁰¹Tl, histopathological differentiation and Na-K ATPase. Methods: Thallium-201 SPECT was performed twice: 15 min (early scan) and 120 min (delayed scan) after intravenous injection of 3 mCi ²⁰¹Tl-chloride. The uptake ratio of ²⁰¹Tl was calculated and compared with the grade of differentiation and the staining pattern of Na-K ATPase. Results: The sensitivity of ²⁰¹Tl SPECT for well-differentiated adenocarcinomas was lower than that for moderately and poorly differentiated ones. The uptake ratio on the delayed scan was significantly lower in the well-differentiated group than that in the moderately and poorly differentiated groups. This parameter was also significantly higher in the Na-K ATPase-positive group than the -negative group. Conclusions: These results indicate that the uptake ratio of ²⁰¹Tl SPECT may be a noninvasive indicator of the grade of pathological differentiation of adenocarcinoma and provide insight into the relationship among ²⁰¹Tl SPECT, malignancy and Na-K ATPase.

Key Words: thallium-201 single-photon emission computed tomography • grade of differentiation • Na-K ATPase • adenocarcinoma of the lung

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