HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Leners, N. Articles by Pauwels, S. Search for Related Content PubMed PubMed Citation Articles by Leners, N. Articles by Pauwels, S.

Indium-111-Pentetreotide Uptake in Endocrine Tumors and Lymphoma

Departments of Nuclear Medicine and Internal Medicine, University of Louvain Medical School, Brussels, Belgium

Correspondence: For correspondence or reprints contact: Stanislas Pauwels, MD, Centre de Médecine Nucléaire, Université Catholique de Louvain, UCL 54.30, Avenue Hippocrate, 54, B-1200 Brussels, Belgium.

ABSTRACT

The biodistribution of ¹¹¹In-pentetreotide was assessed in patients with gastroenteropancreatic (GEP) neuroendocrine tumors or lymphoma and in control patients and analyzed as a function of scanning time, presence or absence of tumor uptake, tumor type and previous octreotide treatment. Methods: Patients underwent imaging 4 and 24 hr after injection of approximately 200 MBq ¹¹¹In-pentetreotide. The frequency of organ visualization was assessed on planar views. Total organ and tumor uptake (% injected dose [ID]) was determined using the geometric mean method and regional tissue uptake (% ID/100 ml) by semiquantitative SPECT. Results: Liver, spleen, kidneys and urinary bladder were visualized in all patients. Thyroid, bowel and pituitary were more often visualized at 24 hr than at 4 hr. Activity in the gallbladder, breast, ureters and ascites was only occasionally observed. Total liver, spleen and thyroid uptake was stable over time, whereas kidney activity decreased slightly. At 24 hr, regional uptake was threefold lower in the liver than in the spleen or kidneys and was similar in the three groups. In patients with long-term octreotide therapy, a positive correlation was found between the duration of octreotide therapy and liver or spleen uptake. Total and regional tumor uptake showed high intraindividual and interindividual variations. Total tumor activity was stable over 24 hr in patients with GEP and decreased in those with lymphoma. The mean regional tumor uptake was 10-fold lower in patients with lymphoma than in those with GEP. Cold octreotide injected 24 hr after tracer administration did not result in any displacement of organ and tumor activity. Conclusion: Organ uptake seems not to be influenced by the presence of ¹¹¹In-pentetreotide-positive lesions or by tumor type. Tumor uptake is highly variable among patients and clearly lower in patients with lymphoma than in those with GEP. The widespread of uptake values in tumors indicates that radiotherapy using radiolabeled somatostatin analogs may not be applicable to all patients with ¹¹¹In-pentetreotide-positive tumors.

Key Words: indium-111-pentetreotide • quantification • endocrine tumors • lymphoma

This article has been cited by other articles:

				C. Dromain, T. de Baere, J. Lumbroso, H. Caillet, A. Laplanche, V. Boige, M. Ducreux, P. Duvillard, D. Elias, M. Schlumberger, et al. Detection of Liver Metastases From Endocrine Tumors: A Prospective Comparison of Somatostatin Receptor Scintigraphy, Computed Tomography, and Magnetic Resonance Imaging J. Clin. Oncol., January 1, 2005; 23(1): 70 - 78. [Abstract] [Full Text] [PDF]

				B. Van Den Bossche and C. Van de Wiele Receptor Imaging in Oncology by Means of Nuclear Medicine: Current Status J. Clin. Oncol., September 1, 2004; 22(17): 3593 - 3607. [Abstract] [Full Text] [PDF]

				V. A.S.H. Dalm, L. J. Hofland, C. M. Mooy, M. A. Waaijers, P. M. van Koetsveld, A. W. Langerak, F. T.J. Staal, A.-J. van der Lely, S. W.J. Lamberts, and M. P. van Hagen Somatostatin Receptors in Malignant Lymphomas: Targets for Radiotherapy? J. Nucl. Med., January 1, 2004; 45(1): 8 - 16. [Abstract] [Full Text] [PDF]

				R. Lebtahi, J. Le Cloirec, C. Houzard, D. Daou, I. Sobhani, G. Sassolas, M. Mignon, P. Bourguet, and D. Le Guludec Detection of Neuroendocrine Tumors: 99mTc-P829 Scintigraphy Compared with 111In-Pentetreotide Scintigraphy J. Nucl. Med., July 1, 2002; 43(7): 889 - 895. [Abstract] [Full Text] [PDF]

				D. Kwekkeboom, E. P. Krenning, and M. de Jong Peptide Receptor Imaging and Therapy J. Nucl. Med., October 1, 2000; 41(10): 1704 - 1713. [Abstract] [Full Text] [PDF]

				M. Raderer, J. Valencak, F. Pfeffel, J. Drach, T. Pangerl, A. Kurtaran, M. Hejna, F. Vorbeck, A. Chott, and I. Virgolini Somatostatin Receptor Expression in Primary Gastric Versus Nongastric Extranodal B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type J Natl Cancer Inst, April 21, 1999; 91(8): 716 - 718. [Full Text] [PDF]